ArticleCureus2025
Serum Procalcitonin as an Indicator of Disease Severity and Clinical Deterioration in Hospitalized Patients With Acute Cholangitis.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Predictors of intensive care unit admission rates in patients with acute cholangitis.World journal of clinical cases · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute cholangitis (AC) results from bile stasis and subsequent infection in the biliary tract, requiring urgent evaluation to determine the timing of biliary decompression. Procalcitonin (PCT) and lactic acid (LAC) may be reliable indicators of disease severity to suggest early biliary decompression. We seek to assess the utility of PCT and LAC to predict severe AC and adverse in-hospital outcomes such as ICU transfer, vasopressor use, or mortality.
methodsThis is a retrospective observational study of patients admitted with AC to a tertiary hospital in the United States between January 1, 2016, and December 31, 2020. Patients were identified using International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) codes for AC. Patients who had both PCT and LAC measured upon presentation were included. Logistic regression analysis was performed to determine the diagnostic performance of PCT and LAC to predict the outcomes.
resultsA total of 193 patients, accounting for 229 hospital encounters, were identified. Choledocholithiasis was the most common cause of biliary obstruction (31.9%), followed by mass or malignancy (21.0%). Endoscopic retrograde cholangiopancreatography
conclusionsThe findings of this study do not support the routine use of PCT in the evaluation of non-malignancy-related AC. PCT may be useful as a predictor of poor in-hospital outcomes in patients with malignancy-related AC. Further research is required to clarify its role in the evaluation of patients with AC.
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