ArticleJournal of thoracic disease2025
Superior surgical tolerance and effectiveness among lung cancer patients who have never versus ever smoked: a retrospective cohort analysis using real-world clinical data.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Mounting evidence suggests that lung cancers differ meaningfully between those with and without a smoking history, including clinical and biological differences that may impact treatment efficiency. However, there is a dearth of real-world, patient-level evidence comparing demographic, clinical, tumor and surgical characteristics of lung cancers among those who have never Methods: Information on patient characteristics, including smoking history, and surgical outcomes was extracted from a real-world thoracic surgery database in New York City. Pearson tests and Spearman tests were used for univariate analysis comparing patients with and without a smoking history; outcomes of surgery were assessed using multivariable logistic regression. Results: Among 1,587 surgically treated lung cancer patients, 332 (20.9%) were cases of lung cancer among those who had never smoked (LCNS) Conclusions: LCNS and LCES surgical patients differ meaningfully in terms of clino-demographic factors. Our results support surgery as a safe and effective treatment option for LCNS.
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