ArticleJournal of thoracic disease2025
Lipid metabolism-related genes regulate the immune microenvironment during ex vivo lung perfusion for lung transplants.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Unveiling the Genomic Landscape of Yan Goose (Animals : an open access journal from MDPI · 2026Article
- Endothelial-targeted modification of ginseng-derived exosomes for IL-6 SiRNA delivery ameliorates hepatic ischemia-reperfusion injury.Journal of nanobiotechnology · 2026Article
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Authors and funding
8 authors.
Funding
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Abstract
Background: Ex vivo lung perfusion (EVLP) serves as a vital platform for donor lung assessment and repair in transplantation. Although lipid metabolism plays a crucial role in pulmonary homeostasis and undergoes alterations during EVLP, the precise regulatory mechanisms linking metabolic changes to immune modulation remain poorly understood. This study aimed to identify key lipid metabolism-related genes governing immune microenvironment remodeling during EVLP and to validate their diagnostic and therapeutic potential. Methods: We analyzed transcriptomic profiles from human donor lungs before and after EVLP using datasets GSE127057 (discovery cohort) and GSE127055 (validation cohort). A comprehensive analytical framework was implemented, incorporating weighted gene co-expression network analysis (WGCNA), protein-protein interaction (PPI) networks, and three machine learning algorithms including least absolute shrinkage and selection operator (LASSO) regression, Random Forest (RF), and eXtreme Gradient Boosting (XGBoost) to identify key lipid metabolism-related genes. Immune cell infiltration patterns were characterized using established computational methods, with subsequent validation in an EVLP model of C57BL/6J wild-type mice. Results: Analysis of GSE127057 revealed 656 differentially expressed genes (DEGs) post-EVLP. Through integrative bioinformatics approaches, three lipid metabolism-related hub genes ( Conclusions: This study establishes UGCG, SAMD8, and MED26 as central regulators of lipid metabolism during EVLP, with their expression patterns correlating with NK cell functional states. These findings provide mechanistic insights into metabolic-immune interactions during donor lung preservation and identify potential biomarkers for clinical monitoring and therapeutic targeting.
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