ArticleJournal of thoracic disease2025
Survival outcomes of thoracic radiotherapy in addition to first-line immunotherapy in metastatic non-small cell lung cancer: a multicenter, propensity score-matched analysis.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
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Abstract
Background: Immune checkpoint inhibitors (ICIs) as part of first-line treatment are becoming increasingly significant in metastatic non-small cell lung cancer (NSCLC). We aimed to investigate the efficacy and safety of thoracic radiotherapy (TRT) in addition to first-line ICIs in metastatic NSCLC. Methods: From January 2017 to August 2023, we retrospectively collected the information of 82 patients with metastatic NSCLC who were treated with first-line ICIs and radiotherapy (RT). Patients were divided into the TRT group (n=35) and the non-TRT group (n=47). The efficacy and safety were analyzed. Propensity score matching (PSM) was applied. Inverse probability of treatment weighting (IPTW) was used as a sensitivity analysis. Results: The median follow-up was 31.4 months (range, 4.0-81.4 months). Before PSM, the median overall survival (OS; 38.1 Conclusions: The addition of TRT to first-line immunotherapy (IO) may be associated with improved survival in metastatic NSCLC. However, given the retrospective nature and limited sample size, these findings are exploratory and warrant validation in larger randomized trials.
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