Evidence map›Paper›PMID 40950835›Full record

ArticleCell reports. Physical science2025

Conformation-gated binding underlies kinetic asymmetry and negative cooperativity in ATP:cob(I)alamin adenosyltransferase.

Guangjie Yan, Manhua Pan, Aaron M Keller, Ace George Santiago, Michael Lofgren, Ruma Banerjee, Peng Chen, Tai-Yen Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Physical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Guangjie YanDepartment of Chemistry, University of Houston, Houston, TX 77204, USA.
Manhua PanDepartment of Chemistry, University of Houston, Houston, TX 77204, USA.
Aaron M KellerDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Ace George SantiagoDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Michael LofgrenDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Ruma BanerjeeDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Peng ChenDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Tai-Yen ChenDepartment of Chemistry, University of Houston, Houston, TX 77204, USA.

Funding

REACTION MECHANISMS OF MAMMALIAN B12-DEPENDENT ENZYMESR01DK045776 · NIDDK · UNIVERSITY OF NEBRASKA LINCOLN · PI RUMA V BANERJEE · 1998 to 2026
$9.7M
Unusual mechanisms of metal regulation in bacteria: from single molecules to single cells to cell communitiesR01GM109993 · NIGMS · CORNELL UNIVERSITY · PI Peng Chen · 2014 to 2026
$3.9M
Quantitative Cu-Homeostasis in Live Mammalian Cells at the Single-Molecule LevelR35GM133505 · NIGMS · UNIVERSITY OF HOUSTON · PI CHEN, TAI-YEN · 2019 to 2023
$2.1M
NIDDK NIH HHS R01 DK045776NIGMS NIH HHS R01 GM109993NIGMS NIH HHS R35 GM133505
6 · The paper itself

Abstract

Vitamin B

Identifiers

PMID40950835
PMCPMC12431680

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.