ArticleInternational journal of women's health2025
Investigating Causal Links Between Uterine Prolapse, Urinary Tract Infections, and Lower Urinary Tract Symptoms: A Two-Sample Mendelian Randomization Study.
Article in International journal of women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Uterine prolapse (UP), a subtype of pelvic organ prolapse (POP), frequently coexists with urinary tract infections (UTIs) and lower urinary tract symptoms (LUTS), including urinary frequency (UF), urinary incontinence (UI), and urinary retention (UR), is a common pelvic floor dysfunction disorder in women. However, the causal relationship between these conditions remains controversial. This study aims to fill this gap by applying two-sample Mendelian randomization. Methods: A two-sample Mendelian randomization (MR) study was conducted to genetically evaluate associations between UP and UTIs/LUTS. The inverse variance weighting (IVW) method served as the primary analysis, supplemented by sensitivity analyses to assess the validity and reliability of results. Results: MR analysis suggested a potential causal link between UP and increased risk of UTIs (p = 0.048). No causal associations were observed between UP and UF, UI, or UR. Sensitivity analyses confirmed stability of results, with no evidence of heterogeneity or horizontal pleiotropy among instrumental variables (IVs). Conclusion: UP may act as a risk factor for UTIs, though further validation is needed given the borderline statistical significance. No clear causal relationships were identified between UP and UF, UI, or UR.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.