ArticleTranslational cancer research2025
Overexpression of miR-1283 inhibits cell proliferation and migration of colorectal cancer cells by targeting PDZD8.
Article in Translational cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: PDZ domain-containing protein 8 (PDZD8) has been implicated in the progression of colorectal cancer. However, its regulatory mechanisms and functional impact remain to be fully elucidated. We assessed PDZD8 expression in colorectal cancer cell lines and normal colorectal mucosa using Real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Methods: The role of PDZD8 in colorectal cancer was further investigated through the generation of PDZD8-depleted HCT 116 and RKO cell models via short hairpin RNA (shRNA) interference. The influence of PDZD8 knockdown on cellular phenotypes was examined through proliferation, migration, apoptosis, and cell cycle assays. Additionally, the regulatory effect of miR-1283 on PDZD8 was explored both Results: PDZD8 messenger RNA (mRNA) expression was significantly upregulated in colorectal cancer cell lines compared to normal mucosa, with the highest expression in RKO and HCT 116 cells. PDZD8 knockdown impeded cell proliferation and migration while promoting apoptosis and cell cycle arrest Conclusions: Our findings revealed that PDZD8 was a critical promoter of malignant phenotypes in colorectal cancer, and its expression was negatively regulated by miR-1283. Targeting the PDZD8/miR-1283 axis may offer a therapeutic strategy for colorectal cancer.
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