ArticleTranslational cancer research2025
Comparisons of the efficacy of different Chinese medicine injections on immune function in patients with nasopharyngeal carcinoma during combined therapy: a systematic review and network meta-analysis.
Article in Translational cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Studies have demonstrated the safety and efficacy of traditional Chinese medicine (TCM) injections combined with concurrent chemoradiotherapy (CCRT) in patients with nasopharyngeal carcinoma (NPC). Although studies have examined the impact on immune function, direct comparisons of the effects of various TCM injections on immune function remain limited. Thus, a Bayesian network meta-analysis (NMA) was conducted to assess the beneficial effects of different TCM injections on immune function in patients with NPC during CCRT. Methods: The PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang, Weipu, and China Biology Medicine disc (CBM) databases were searched up to February 2025. The key inclusion criteria incorporated-(I) study subjects: individuals with clinically and pathologically confirmed NPC; (II) the control group received CCRT, and the study group received TCM injections combined with CCRT. The TCM injections of interest were Aidi (AD), Fufangkushen (FFKS), Kushensu (KSS), Shenqifuzheng (SQFZ), Lanxiangxi (LXX), etc.; (III) study type: a randomized controlled trial (RCT); (IV) outcome indicators: CD3 Results: This NMA encompassed 11 eligible articles involving 983 patients (496 in the CCRT + TCM injection group and 487 in the CCRT group). Seven TCM injections and four outcome indicators were considered. Due to the inability to implement blinding, all included articles presented a low risk of bias. The results demonstrated that AD injection was the most effective in improving CD3 Conclusions: This NMA demonstrated that TCM injections significantly increased the levels of peripheral blood CD3
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