ArticleTranslational cancer research2025
Role of the transcription factor
Article in Translational cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
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Abstract
Background: Lymph node metastasis (LNM) is one of the forms of hepatocellular carcinoma (HCC) dissemination, a phenomenon that is strongly correlated with an adverse prognosis. The transcription factor Methods: We retrospectively enrolled 387 HCC patients who underwent radical hepatectomy with lymph-node dissection between 2013 and 2021, among whom 57 were LNM-positive and the remaining 330 were negative. Recurrence-free survival (RFS) and overall survival (OS) were estimated using Kaplan-Meier curves and compared by log-rank test; independent prognostic factors were identified with Cox proportional-hazards regression. Results: LNM, microvascular invasion (MVI), and the China Liver Cancer (CNLC) stage emerged as independent predictors of both shorter RFS and OS in the matched cohort; metastatic lymph nodes exhibited a 3.8-fold increase in Conclusions: In summation, this study established a correlation between LNM and diminished RFS and OS among HCC patients. Moreover, it demonstrated the significant role of
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