ArticleFrontiers in microbiology2025
A longitudinal molecular surveillance of genetic heterogeneity of
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- A Compact Closed Genome ofPathogens (Basel, Switzerland) · 2026Article
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Abstract
Background: Scrub typhus (ST), is a vector borne zoonotic disease, transmitted by the larva of the trombiculid mites. The enzootic cycle of the pathogen involves rodents/shrews as the animal reservoirs and humans are the accidental dead-end host. A transposon-like activity in its major antigen 56 kDa, has led to the evolution of several serotypes/strains, and more than 40 serotypes are reported globally. Puducherry, India, is endemic to scrub, but limited data exist on local serotype distribution across hosts and vectors. Methodology: A longitudinal molecular surveillance was conducted in Puducherry to investigate the genetic diversity of Result: ST infection was detected in 4.37% (95% CI: 3.05-5.71%) of human, 11.52% (95% CI: 8.6-14.4%) of rodent/shrew, and 2.36% (95% CI: 0.95-4.87%) of mite samples. Karp-like (51.72%) and Gilliam-like (41.38%) strains were predominant in both humans and animal hosts, with pairwise genetic distance (<0.1) and amino acid identity (>85%) analysis revealing a close relationship between the strains identified across the region. Notably, the only mite pool that tested positive for the 56 kDa gene, along with a shrew, was identified to belong to the TA678-like serotype (6.90%), which has not been previously reported from Puducherry. Conclusion: This study provides molecular evidence of the enzootic maintenance and active human transmission of
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