Evidence map›Paper›PMID 40950557›Full record

ArticleEuropean physical journal plus2025

Hybrid compton-PET imaging for ion-range verification: a preclinical study for proton, helium, and carbon therapy at HIT.

Javier Balibrea-Correa, Jorge Lerendegui-Marco, Ion Ladarescu, Sergio Morell, Carlos Guerrero, Teresa Rodríguez-González, Maria Del Carmen Jiménez-Ramos, Jose Manuel Quesada, Julia Bauer, Stephan Brons and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European physical journal plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Javier Balibrea-CorreaFísica Nuclear Experimental, Instituto de Fisica Corpuscular CSIC-University of Valencia, Catedrátic José Beltrán Martinez, 2, Valencia, 46980 Spain.ORCID 0000-0002-8404-3256
Jorge Lerendegui-MarcoFísica Nuclear Experimental, Instituto de Fisica Corpuscular CSIC-University of Valencia, Catedrátic José Beltrán Martinez, 2, Valencia, 46980 Spain.
Ion LadarescuFísica Nuclear Experimental, Instituto de Fisica Corpuscular CSIC-University of Valencia, Catedrátic José Beltrán Martinez, 2, Valencia, 46980 Spain.
Sergio MorellFísica Nuclear Experimental, Instituto de Fisica Corpuscular CSIC-University of Valencia, Catedrátic José Beltrán Martinez, 2, Valencia, 46980 Spain.
Carlos GuerreroDepartamento de Física Nuclear y Atómica y Molecular, University of Seville, Sevilla, 41012 Andalucia Spain.
Teresa Rodríguez-GonzálezDepartamento de Física Nuclear y Atómica y Molecular, University of Seville, Sevilla, 41012 Andalucia Spain.
Maria Del Carmen Jiménez-RamosAceleradores,Centro Nacional de Aceleradores (U. Sevilla, CSIC, Junta de Andalucía), C. Tomás Alva Edison, 7, Sevilla, 41092 Andalucia Spain.
Jose Manuel QuesadaDepartamento de Física Nuclear y Atómica y Molecular, University of Seville, Sevilla, 41012 Andalucia Spain.
Julia BauerDepartment Of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany.
Stephan BronsDepartment Of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany.
César Domingo-PardoFísica Nuclear Experimental, Instituto de Fisica Corpuscular CSIC-University of Valencia, Catedrátic José Beltrán Martinez, 2, Valencia, 46980 Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enhanced-accuracy ion-range verification in real time shall enable a significant step forward in the use of therapeutic ion beams. Positron-emission tomography (PET) and prompt-gamma imaging (PGI) are two of the most promising and researched methodologies, both of them with their own advantages and challenges. Thus far, both of them have been explored for ion-range verification in an independent way. However, the simultaneous combination of PET and PGI within the same imaging framework may open-up the possibility to exploit more efficiently all radiative emissions excited in the tissue by the ion beam. Here, we report on the first preclinical implementation of an hybrid PET-PGI imaging system, hereby exploring its performance over several ion beam species (H, He and C), energies (55-275 MeV) and intensities (

Identifiers

PMID40950557
PMCPMC12425852

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.