Evidence map›Paper›PMID 40950529›Full record

ArticleNeurophotonics2026

Linking brain activation to clinical outcomes: an fNIRS study in cochlear implant users and normal hearing individuals.

András Bálint, Wilhelm Wimmer, Christian Rummel, Marco Caversaccio, Stefan Weder

Abstract read
In one paragraph

Article in Neurophotonics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

András BálintUniversity of Bern, ARTORG Center for Biomedical Engineering Research, Hearing Research Laboratory, Bern, Switzerland.ORCID https://orcid.org/0000-0002-7904-0384
Wilhelm WimmerBern University Hospital, University of Bern, Inselspital, Department of ENT - Head and Neck Surgery, Bern, Switzerland.ORCID https://orcid.org/0000-0001-5392-2074
Christian RummelBern University Hospital, University of Bern, University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Support Center for Advanced Neuroimaging (SCAN), Bern, Switzerland.ORCID https://orcid.org/0000-0003-2345-7938
Marco CaversaccioUniversity of Bern, ARTORG Center for Biomedical Engineering Research, Hearing Research Laboratory, Bern, Switzerland.ORCID https://orcid.org/0000-0002-7090-8087
Stefan WederBern University Hospital, University of Bern, Inselspital, Department of ENT - Head and Neck Surgery, Bern, Switzerland.ORCID https://orcid.org/0000-0002-2079-2047

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Significance: Cochlear implants (CIs) are a proven intervention for severe hearing loss; however, outcomes vary widely among CI recipients. Emerging evidence suggests that cortical adaptation to the electric hearing provided by CIs play a crucial role. Aim: We investigate cortical brain activation differences in CI users, comparing individuals with good speech understanding (good performers, GP) to those with poor outcomes (poor performers, PP) alongside a control group with normal hearing (NH). Approach: We recruited 46 CI users and 26 NH participants to perform a clinically adapted audiovisual speech comprehension task while we measured their brain activity using functional near-infrared spectroscopy (fNIRS). We corroborated our findings with objective and behavioral data. Results: Our findings showed distinct brain activation patterns associated with speech understanding. GP showed comparable brain activation patterns to NH in audio-only conditions, indicative of successful hearing rehabilitation. Further, both GP and PP participants showed an adaptive mechanism during visual speech processing. However, compared with GP, PP relied heavily on visual cues and showed altered neural resource allocation during audio-only conditions, potentially limiting their overall rehabilitation success. Conclusions: fNIRS revealed significant differences in brain activation between GP and PP, highlighting the role of cortical factors in CI rehabilitation. Understanding these neural mechanisms has the potential to lead to better patient counseling, optimized postoperative management, and personalized therapeutic strategies to improve outcomes for CI users.

Indexed as

brain imagingbrain plasticitycochlear implantfunctional near-infrared spectroscopyspeech understanding

Identifiers

PMID40950529
PMCPMC12425163

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.