Evidence map›Paper›PMID 40950474›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Integrative genomics elucidates the evolutionary, temporal, and developmental origins of a hydrocephalus risk gene.

Andrew T Hale, Yuwei Song, Caroline Davies, Shanrun Liu, Regan Gaskin, Anastasia Arynchyna-Smith, Brandon G Rocque, Zechen Chong

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Andrew T HaleDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.ORCID 0000-0003-3182-2966
Yuwei SongDepartment of Biomedical Informatics and Data Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Caroline DaviesDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Shanrun LiuSingle cell and flow cytometry core, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Regan GaskinDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Anastasia Arynchyna-SmithDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Brandon G RocqueDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Zechen ChongSingle cell and flow cytometry core, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.

Funding

Structural variation analysis with and without a reference genomeR35GM138212 · NIGMS · UNIVERSITY OF VIRGINIA · PI Zechen Chong · 2020 to 2026
$2.6M
Understanding the mechanisms of congenital hydrocephalus using genomic sequencing approachesR21NS135321 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHONG, ZECHEN, ROCQUE, BRANDON GEORGE · 2023 to 2023
$393k
NIGMS NIH HHS R35 GM138212NINDS NIH HHS R21 NS135321
6 · The paper itself

Abstract

Introduction: A prior integrative, multi-omics human genetics and functional genomics study identified maelstrom ( Objective: To characterize the evolutionary, temporal, developmental, and lineages of Methods: Ensembl was used to delineate the evolution and taxonomy of Results: We performed taxonomic gene-mapping to define the evolutionary origin of Conclusions: We identify the evolutionary, temporal, and developmental expression pattern of

Identifiers

PMID40950474
PMCPMC12424877

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.