ArticlemedRxiv : the preprint server for health sciences2025
Disparities in Cardiovascular Disease in Women with Adverse Pregnancy Outcomes.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
11 authors.
Funding
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Abstract
Background: Although adverse pregnancy outcomes (APOs) have been linked to increased cardiovascular disease (CVD) risk, most studies have focused on homogenous populations. We tested the hypothesis that APOs and race and ethnicity synergistically increase the risk of CVD. Methods: We conducted retrospective analyses of data collected by Results: We included 10,760 women in our analysis, who had a mean (SD) age of 30 (±6) years at first delivery. Of these, 4,204 (39%) had at least one APO. After a median (interquartile range) follow-up of 7.02 (3.82-13.26) years, 217 (5.2%) women with APO sustained CVD, while only 252 (3.8%) without APO did ( Conclusions: In a large and diverse cohort of American women with a single lifetime delivery, APOs were associated with an increased risk of CVD, and these risks were even greater among Black women. These findings highlight the potential to integrate reproductive health history and non-medical determinants of health to enhance CVD prevention and health equity using personalized medicine. Further research is needed to identify the mechanisms that lead to synergistic contributions by APOs and race and ethnicity.
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