ReviewFrontiers in cell and developmental biology2025
Exploring the protective effects of coenzyme Q10 on female fertility.
Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Serum anti-Müllerian hormone response to pyrroloquinoline quinone supplementation in healthy women: no overall change and exploratory subgroup findings.Frontiers in endocrinology · 2026Trial
- Mitochondrial Function and Dysfunction in Female Fertility: Biological Mechanisms, Genetic Determinants, and Therapeutic Opportunities - A Review.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Nutritional Regulation of Ovarian Bioenergetics: Implications for Reproductive Aging and Female Infertility.Nutrients · 2026Review
- Modulatory Effects of Antioxidant Supplementation on Serum Oxidative Stress Biomarkers MDA and T-AOC in Females with Unexplained Infertility.Antioxidants (Basel, Switzerland) · 2026Article
- Review
- Mechanisms of inflammation in premature ovarian insufficiency and advances in therapeutic studies.Frontiers in immunology · 2026Review
- The Impact of Oxidative Stress Imbalance on Ovarian Function and Its Mechanisms.International journal of general medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The global decline in fertility rates has intensified the reliance on assisted reproductive technology (ART) for infertility treatment. Antioxidant supplementation, particularly with coenzyme Q10 (CoQ10), has gained prominence as a therapeutic strategy to enhance fertility outcomes and ART success. As a lipid-soluble benzoquinone, CoQ10 plays dual roles in the metabolism of mitochondrial energy and antioxidant protection. By regulating oxidative stress and reducing reactive oxygen species (ROS), CoQ10 improves oocyte quality, ovarian function, and mitochondrial efficiency, thereby optimizing ART outcomes. Clinical studies demonstrate that CoQ10 supplementation enhances ovarian function, increases the number of eggs, and improves the quality of embryo, particularly in women with weak ovarian reserve functions or older age. This review synthesizes current evidence on CoQ10's mechanisms in safeguarding female fertility, including its effects on oocyte maturation, embryonic development, and ovarian aging. Furthermore, it explores CoQ10's potential in addressing conditions such as premature ovarian failure and polycystic ovary syndrome. This review provides an overview of CoQ10's protective effect on female fertility and its potential clinical application in reproductive medicine, aiming to offer guidance for the future use of CoQ10 in ART clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.