ArticleJournal of gastrointestinal oncology2025
Poorer prognosis of early gastric cardia cancer compared to early gastric non-cardia cancer: evidence from SEER database analysis.
Article in Journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Excess late mortality among long-term gastric cancer survivors following gastrectomy: a population-based cohort study.Journal of gastrointestinal oncology · 2026Article
- Survival outcomes in early gastric cancer: evidence from SEER-based population studies.Journal of gastrointestinal oncology · 2026Article
- Integrative management of gastric cardia cancer and precancerous lesions: prospects and mechanistic rationale for Banxia Xiexin Tang.Frontiers in pharmacology · 2026Review
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7 authors.
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Abstract
Background: Limited evidence and contradictory results exist regarding lymph node metastasis (LNM) and prognosis in early gastric cardia cancer (EGCC) and early gastric non-cardia cancer (EGNCC). This study aims to compare the clinicopathological features, LNM patterns, and survival outcomes between EGCC and EGNCC using a large population-based dataset. Methods: This study utilized data from the Surveillance, Epidemiology, and End Results (SEER) population and employed multivariate analysis, Kaplan-Meier method, propensity score matching (PSM), and nomogram analysis to achieve comprehensive insights. Results: EGCC tended to be younger in age, intestinal type, smaller tumor size, and well-differentiated type (P<0.05). No positive association was found between LNM and tumor location after adjusting for other risk factors [odds ratio (OR): 0.87; 95% confidence interval (CI): 0.60-1.25; P=0.44]. Moreover, patients with EGNCC showed a better prognosis compared with EGCC patients [5-year disease-specific survival (DSS): 87.3% Conclusions: The risk of LNM in EGCC is comparable to that in EGNCC. However, EGCC exhibits poorer survival outcomes compared to EGNCC. This discovery underscores the importance of enhanced monitoring and individualized treatment approaches for patients with EGCC to improve their prognosis and survival.
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