ArticleJournal of gastrointestinal oncology2025
Efficacy of stereotactic body radiotherapy in hepatocellular carcinoma with adrenal metastases: a retrospective analysis.
Article in Journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Radiotherapy for Adrenal Metastases from Hepatocellular Carcinoma: A 20-Year Bi-Institutional Experience.Current oncology (Toronto, Ont.) · 2026Article
- A glimpse into the CyberKnife robotic radiosurgery system: technical specifications and developments during thirty years.Frontiers in oncology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hepatocellular carcinoma (HCC) with adrenal metastasis is associated with poor prognosis and lacks standardized treatment strategies. Stereotactic body radiotherapy (SBRT) is a promising non-invasive option, yet its efficacy in this setting remains underexplored. This study aims to evaluate the efficacy and safety of SBRT in managing HCC patients with adrenal metastasis, focusing on factors influencing local control (LC) and overall survival (OS). Methods: This retrospective study included 52 HCC patients with adrenal metastases treated with SBRT using the CyberKnife system between February 2016 and March 2022. Gross tumor volume (GTV) and biologically effective dose (BED) were calculated, and LC and OS were analyzed. Prognostic factors were assessed using univariate and multivariate Cox regression. Results: At a median follow-up of 12.5 months, the overall response rate was 86.0%, with LC rates of 100%, 81.7%, and 75.8% at 6 months, 1 year, and 2 years, respectively. The median OS was 22 months. Intrahepatic tumor control and absence of extra-organ metastases were independently associated with improved OS (P=0.01 and P=0.001, respectively). No grade ≥2 adverse reactions were observed. Conclusions: CyberKnife-based SBRT provides high LC rates and acceptable survival outcomes in HCC patients with adrenal metastases. Intrahepatic lesion control and extrahepatic disease burden are key factors influencing prognosis. SBRT should be considered as a local treatment strategy in multidisciplinary management of this population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.