Evidence map›Paper›PMID 40950225›Full record

ArticlebioRxiv : the preprint server for biology2025

A conserved Hsp70 phosphorylation regulates cell cycle progression after DNA damage.

Thomas Moss, Alexandra Wooldredge, Koustav Bhakta, Matthew Cronin, Jason E Gestwicki, Shaeri Mukherjee

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Thomas MossG.W. Hooper foundation, University of California at San Francisco, San Francisco, USA.ORCID 0000-0003-3647-9319
Alexandra WooldredgeG.W. Hooper foundation, University of California at San Francisco, San Francisco, USA.
Koustav BhaktaG.W. Hooper foundation, University of California at San Francisco, San Francisco, USA.
Matthew CroninG.W. Hooper foundation, University of California at San Francisco, San Francisco, USA.
Jason E GestwickiDepartment of Pharmaceutical Chemistry and the Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-6125-3154
Shaeri MukherjeeG.W. Hooper foundation, University of California at San Francisco, San Francisco, USA.ORCID 0000-0003-3820-0174

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
Molecular Chaperones and Small MoleculesR01NS059690 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jason E Gestwicki · 2008 to 2026
$7.9M
Microbial Pathogenesis and Host DefenseT32AI060537 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joanne N. Engel · 2004 to 2026
$6.5M
Legionella effectors reveal novel signaling function for the ribosome quality control (RQC) pathwayR01GM140440 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MUKHERJEE, SHAERI · 2021 to 2024
$1.7M
Role of HSC70 in protein synthesisR01GM144378 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MUKHERJEE, SHAERI · 2022 to 2025
$1.3M
NIAID NIH HHS T32 AI060537NIDDK NIH HHS P30 DK063720NIGMS NIH HHS R01 GM140440NIGMS NIH HHS R01 GM144378NINDS NIH HHS R01 NS059690
6 · The paper itself

Abstract

Hsp70s are essential molecular chaperones that are increasingly recognized to be regulated by post-translational modifications. Here, we show that phosphorylation of a conserved threonine (T495), previously shown to be exploited by a

Identifiers

PMID40950225
PMCPMC12424849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.