Evidence map›Paper›PMID 40950224›Full record

ArticlebioRxiv : the preprint server for biology2025

ACTL6A regulates the Warburg effect through coordinated activation of AP-1 signaling in head and neck squamous cell carcinoma.

Mehri Monavarian, Alistaire R Sherman, Imran A Mohammad, Sainiteesh Maddineni, Mao Zhang, Joseph C Wu, Katrin F Chua, John Sunwoo, Andrey Finegersh

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mehri MonavarianDepartment of Otolaryngology, Stanford University, Palo Alto, CA.
Alistaire R ShermanDepartment of Otolaryngology, Stanford University, Palo Alto, CA.
Imran A MohammadDepartment of Otolaryngology, Stanford University, Palo Alto, CA.
Sainiteesh MaddineniDepartment of Otolaryngology, Stanford University, Palo Alto, CA.
Mao ZhangDepartment of Medicine, Stanford University, Palo Alto, CA.
Joseph C WuDepartment of Medicine, Stanford University, Palo Alto, CA.
Katrin F ChuaDepartment of Medicine, Stanford University, Palo Alto, CA.
John SunwooDepartment of Otolaryngology, Stanford University, Palo Alto, CA.
Andrey FinegershDepartment of Otolaryngology, Stanford University, Palo Alto, CA.

Funding

ACTL6a ties metabolic reprogramming to cancer stem cell maintenance in oral cavity squamous cell carcinomaR03DE034489 · NIDCR · STANFORD UNIVERSITY · PI FINEGERSH, ANDREY · 2025 to 2025
$308k
NIDCR NIH HHS R03 DE034489
6 · The paper itself

Abstract

ACTL6a is an essential component of SWI/SNF and expressed on the chromosome 3q26 cytoband, which is amplified in head and neck squamous cell carcinomas (HNSCC). While ACTL6A is emerging as an oncogene, its role as a treatment target and mechanisms of transcription factor induction remain unknown. Here, we show that ACTL6A expression is a mediator of the Warburg effect, with ACTL6A knockdown inducing mitochondrial dependency and significantly decreasing levels of aerobic glycolysis. These effects lead to near complete attenuation of hypoxic cell growth by blunting induction of HIF1α and HIF2α protein expression. They also sensitize treatment resistant HNSCC cells to the tumor killing effects of the complex I inhibitor IACS-010759

Identifiers

PMID40950224
PMCPMC12424702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.