Evidence map›Paper›PMID 40950207›Full record

ArticlebioRxiv : the preprint server for biology2025

Structural Homology and Electrostatic Potential Comparisons of Epitope Pair Candidates for Molecular Mimicry Triggering of Type 1 Diabetes Mellitus.

Ryan Gardner, Joshua Wilkins, Sejal Mistry, Ramkiran Gouripeddi, Julio C Facelli

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Ryan GardnerWeber State University and University of Wisconsin-Madison.
Joshua WilkinsNorth Carolina A&T.
Sejal MistryDepartment of Biomedical Informatics.
Ramkiran GouripeddiDepartment of Biomedical Informatics.
Julio C FacelliDepartment of Biomedical Informatics.ORCID 0000-0003-1449-477X

Funding

CTSA UM1 Program at University of UtahUM1TR004409 · NCATS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI RACHEL HESS, Jennifer Juhl Majersik · 2023 to 2026
$21.9M
CTSA R25 Program at University of Utah: Biomedical Research Inclusion & Diversity to Grow Excellence in science Undergraduate Program for HBCUs (BRIDGE UP–HBCU)R25TR004388 · NCATS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ANGELA FAGERLIN, Keke Celeste Fairfax · 2023 to 2026
$432k
Identifying Temporal Sequences of Exposures in Type 1 Diabetes EtiologyF30DK134113 · NIDDK · UNIVERSITY OF UTAH · PI MISTRY, SEJAL · 2022 to 2024
$144k
NCATS NIH HHS R25 TR004388NCATS NIH HHS UM1 TR004409NIDDK NIH HHS F30 DK134113
6 · The paper itself

Abstract

Background: Molecular mimicry, where foreign and self-peptides contain similar epitopes, can induce autoimmune responses. Identifying potential molecular mimics and studying their properties is key to understanding the onset of autoimmune diseases such as type 1 diabetes mellitus (T1DM). Previous work identified pairs of infectious epitopes (E Results: For each pair of E Conclusions: Most of the E

Indexed as

Molecular MimicryProtein Structure PredictionType 1 Diabetes Mellitus

Identifiers

PMID40950207
PMCPMC12424643

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.