Evidence map›Paper›PMID 40950197›Full record

ArticlebioRxiv : the preprint server for biology2025

Structural Basis for Childhood Antibody Recognition of The Human Metapneumovirus Fusion Protein.

Ahmed Magdy Khalil, Behrouz Ghazi Esfahani, Rose J Miller, Jiachen Huang, Guillermina Kuan, Angel Balmaseda, Aubree Gordon, Jarrod J Mousa

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Ahmed Magdy KhalilDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, USA.
Behrouz Ghazi EsfahaniDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, USA.
Rose J MillerDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
Jiachen HuangDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
Guillermina KuanSustainable Sciences Institute, Managua, Nicaragua.
Angel BalmasedaSustainable Sciences Institute, Managua, Nicaragua.
Aubree GordonSchool of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-9352-7877
Jarrod J MousaDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, USA.

Funding

Epidemiology, transmission, and phylogenetics of influenza in a tropical countryU01AI088654 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI GORDON, AUBREE L, HARRIS, EVA · 2010 to 2014
$3.2M
Structural and mechanistic insights into antibody neutralization of human metapneumovirusR01AI143865 · NIAID · UNIVERSITY OF GEORGIA · PI MOUSA, JARROD · 2019 to 2023
$3.0M
NIAID NIH HHS R01 AI143865NIAID NIH HHS U01 AI088654
6 · The paper itself

Abstract

Human metapneumovirus (hMPV) is a significant cause of acute respiratory illness in children and adults, with the majority of children being seropositive for hMPV by five years of age. Infants, older adults, and immunocompromised individuals are more susceptible to severe hMPV infections that can lead to hospitalization and death. The hMPV fusion (F) protein is the sole target of neutralizing antibodies, and while the most common neutralizing epitopes on the hMPV F protein targeted by B cells in hMPV-infected adults have been previously determined, the antibody response in hMPV-infected children remains undefined. We isolated a panel of human monoclonal antibodies (mAbs) from children previously infected with hMPV (MPV498, MPV499, MPV510, MPV511, and MPV513), and the mAbs were assessed for binding avidity, neutralization potency, epitope specificity, and

Identifiers

PMID40950197
PMCPMC12424945

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.