Evidence map›Paper›PMID 40950183›Full record

ArticlebioRxiv : the preprint server for biology2025

A choanoflagellate cGLR-STING pathway reveals evolutionary links between bacterial and animal immunity.

Yao Li, Hunter C Toyoda, Samantha G Fernandez, Bianca Tiwari, Collin McNairy, Arielle Woznica, Philip J Kranzusch

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yao LiDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-4741-4799
Hunter C ToyodaDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
Samantha G FernandezDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
Bianca TiwariDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
Collin McNairyDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, 78712, USA.
Arielle WoznicaDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, 78712, USA.
Philip J KranzuschDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.

Funding

Discovery of cGAS-like signaling enzymes in innate immunity and diseaseDP2GM146250 · NIGMS · DANA-FARBER CANCER INST · PI KRANZUSCH, PHILIP J · 2021 to 2024
$2.5M
NIGMS NIH HHS DP2 GM146250
6 · The paper itself

Abstract

Animal innate immunity evolved from ancient pathways in bacterial anti-phage defense. How bacterial immune components were first acquired and adapted within eukaryotic cells remains poorly understood. Here we identify a complete cGLR-STING signaling axis in choanoflagellates, the closest living relatives of animals, that exhibits a mosaic of features from both bacterial and animal immunity. Comparative genomics reveals choanoflagellate

Identifiers

PMID40950183
PMCPMC12424679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.