Evidence map›Paper›PMID 40950176›Full record

ArticlebioRxiv : the preprint server for biology2025

Real-time in vivo imaging of rodent brain response to hypoperfusion enabled by remotely controlled elastomeric micro-balloons.

Jong Bin Kim, Jinghui Wang, Yinding Chi, Jingxian Wu, Alicia Ng, Guanda Qiao, Honglin Tan, Miroslaw Janowski, Piotr Walczak, Yajie Liang and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Jong Bin KimDepartment of Material Science and Engineering, University of Pennsylvania, 3231 Walnut Street, Philadelphia, PA 19104, USA.
Jinghui WangDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201 USA.
Yinding ChiDepartment of Material Science and Engineering, University of Pennsylvania, 3231 Walnut Street, Philadelphia, PA 19104, USA.
Jingxian WuDepartment of Material Science and Engineering, University of Pennsylvania, 3231 Walnut Street, Philadelphia, PA 19104, USA.
Alicia NgDepartment of Material Science and Engineering, University of Pennsylvania, 3231 Walnut Street, Philadelphia, PA 19104, USA.
Guanda QiaoDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201 USA.
Honglin TanDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201 USA.
Miroslaw JanowskiDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201 USA.
Piotr WalczakDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201 USA.
Yajie LiangDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201 USA.
Shu YangDepartment of Material Science and Engineering, University of Pennsylvania, 3231 Walnut Street, Philadelphia, PA 19104, USA.

Funding

Image-guided intra-arterial administration of antibody-releasing glial progenitors to control the HIV CNS reservoir.R01DA056739 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI Alonso Heredia, Piotr Walczak · 2022 to 2026
$3.0M
Shedding light on functional heterogeneity of dementia-related alpha-synuclein strainsR21AG077631 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI LIANG, YAJIE · 2022 to 2022
$463k
Altered pH in early Alzheimer's disease detected by creatine chemical exchange saturation transfer MRIR21AG074978 · NIA · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI XU, JIADI · 2022 to 2022
$444k
Intravital 2-photon microscopy enabling 6D single cell RNA seq in immunocompetent glioblastoma xenograftsR03NS123733 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI LIANG, YAJIE · 2021 to 2022
$155k
Intravital 2-photon imaging the integration of transplanted embryonic neurons in a mouse model of cerebral ischemia at the subacute phaseR03NS128459 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI LIANG, YAJIE · 2022 to 2023
$155k
NIA NIH HHS R21 AG074978NIA NIH HHS R21 AG077631NIDA NIH HHS R01 DA056739NINDS NIH HHS R03 NS123733NINDS NIH HHS R03 NS128459
6 · The paper itself

Abstract

Current preclinical models of ischemic stroke in mice do not permit simultaneous and continuous in vivo brain imaging during the peri-stroke period, therefore missing critical pathophysiological events that could be pivotal for stroke management at the early stage. Here we report remote control of the blood flow of cerebral arteries in live mice continuously at different states to induce stroke in a precise, reliable, and reversible manner. The sub-millimeter scale micro-balloons can expand more than four times their initial diameter, featuring a monolithic elastomeric wall with selectively stiffened regions for controlled inflation and elasticity depending on the target vessels. By allowing for the control of common carotid artery diameter through a cuff pressing against the artery, the micro-balloon recapitulates clinically relevant haemodynamics in a mouse model of global brain ischemia, evidenced by real-time imaging of the brain through intravital microscopy and magnetic resonance imaging. The presented micro-balloons hold significant potential to improve the treatment of stroke patients for minimally invasive intervention and in vivo imaging of the pathophysiological events in the peri-stroke phase.

Identifiers

PMID40950176
PMCPMC12424670

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.