Evidence map›Paper›PMID 40950155›Full record

ArticlebioRxiv : the preprint server for biology2025

JARID2 Inhibition Reprograms Human Hematopoietic Progenitor Cells To Enhance Bone Marrow Transplantation.

Wentao Han, Hassan Bjeije, Hamza Celik, Michael Rettig, Nancy Issa, Andrew L Young, Yanan Li, Infencia Xavier Raj, Christine R Zhang, Aishwarya Krishnan and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Wentao HanDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Hassan BjeijeDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Hamza CelikDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Michael RettigDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Nancy IssaDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Andrew L YoungDivision of Hematology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Yanan LiDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Infencia Xavier RajDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Christine R ZhangDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Aishwarya KrishnanDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Tyler M ParsonsDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Samantha C BurkartDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Jason ArandDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Wei YangDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Jeffrey A MageeDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA, 63110.
Grant A ChallenDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA, 63110.ORCID 0000-0003-4669-8814

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
PRE-AND POSTGRADUATE TRAINING IN MOLECULAR HEMATOLOGYT32HL007088 · NHLBI · WASHINGTON UNIVERSITY · PI Grant Anthony Challen, Stephen Oh · 1985 to 2026
$14.1M
The role of Kmt2c/MLL3 in hematopoietic stem cell self-renewal, commitment and exhaustionR01HL152180 · NHLBI · WASHINGTON UNIVERSITY · PI Jeffrey Alan Magee · 2020 to 2026
$3.0M
Inflammatory Stress Promotes Clonal Expansion of DNMT3A-mutant HSCsR01DK124883 · NIDDK · WASHINGTON UNIVERSITY · PI Grant Anthony Challen · 2020 to 2026
$2.5M
Functions of JARID2 in Normal and Neoplastic HematopoiesisR01HL147978 · NHLBI · WASHINGTON UNIVERSITY · PI CHALLEN, GRANT ANTHONY · 2019 to 2022
$1.6M
Manipulating the Stem Cell Epigenome to Improve Bone Marrow TransplantationR01DK119231 · NIDDK · WASHINGTON UNIVERSITY · PI CHALLEN, GRANT ANTHONY · 2019 to 2021
$849k
Impact of Clonal Hematopoiesis on Solid Tumor Development and Response to TherapyK99CA296777 · NCI · WASHINGTON UNIVERSITY · PI Tyler Matthew Parsons · 2025 to 2026
$204k
Integration of HSC Stress Responses and Disease Progression by DNMT3A MutationsK99HL165103 · NHLBI · WASHINGTON UNIVERSITY · PI ZHANG, CHRISTINE R · 2022 to 2023
$178k
NCI NIH HHS K99 CA296777NCI NIH HHS P30 CA091842NHLBI NIH HHS K99 HL165103NHLBI NIH HHS R01 HL147978NHLBI NIH HHS R01 HL152180NHLBI NIH HHS T32 HL007088NIDDK NIH HHS R01 DK119231NIDDK NIH HHS R01 DK124883
6 · The paper itself

Abstract

Hematopoietic stem cell transplantation is a common treatment for many blood disorders and can be a life-saving therapy for patients with leukemias, lymphomas and multiple myeloma. Umbilical cord blood (UCB) serves as a valuable source of hematopoietic stem and progenitor cells (HSPCs) for transplantation, particularly for patients lacking a matched donor. However, the limited number of repopulating cells in UCB units restricts its clinical utility. Our prior studies showed that genetic deletion of the polycomb repressive complex 2 (PRC2) co-factor

Identifiers

PMID40950155
PMCPMC12424646

What OpenQuestion holds

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LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.