Evidence map›Paper›PMID 40950154›Full record

ArticlebioRxiv : the preprint server for biology2025

Age-Related Changes in Curiosity: The Influence of Locus Coeruleus on Information-Seeking Behavior.

Hsiang-Yu Chen, Emma Lepore Carlson, McKenna S Costello, Johanna L Matulonis, Alex A Adornato, Katherine E O'Malley, Jacob M Hooker, Heidi I L Jacobs, Anne S Berry

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hsiang-Yu ChenDepartment of Psychology, Brandeis University.ORCID 0000-0003-2531-536X
Emma Lepore CarlsonDepartment of Psychology, Brandeis University.
McKenna S CostelloDepartment of Psychology, Brandeis University.
Johanna L MatulonisDepartment of Psychology, Brandeis University.
Alex A AdornatoDepartment of Psychology, Brandeis University.
Katherine E O'MalleyDepartment of Psychology, Brandeis University.
Jacob M HookerAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital.
Heidi I L JacobsAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital.
Anne S BerryDepartment of Psychology, Brandeis University.

Funding

Upregulated Norepinephrine Synthesis Capacity in AgingR01AG074330 · NIA · BRANDEIS UNIVERSITY · PI Anne Shively Berry · 2022 to 2026
$6.2M
Age effects on memory and reward systems in decision makingR00AG058748 · NIA · BRANDEIS UNIVERSITY · PI BERRY, ANNE SHIVELY · 2019 to 2021
$745k
Aging, activity diversity, and brain healthR21AG086729 · NIA · BRANDEIS UNIVERSITY · PI BERRY, ANNE SHIVELY · 2024 to 2024
$457k
NIA NIH HHS R00 AG058748NIA NIH HHS R01 AG074330NIA NIH HHS R21 AG086729
6 · The paper itself

Abstract

Curiosity enhances learning and memory and has been linked to the locus coeruleus (LC), which undergoes age-related decline. To examine how aging affects curiosity and information-seeking, we developed the Photographic Art Storytelling Task. Participants (sixty-eight young and sixty-five older adults) viewed photographs, rated their curiosity, and later read stories associated with selected images. The stories were deliberately constructed to be either interesting or boring, functioning as rewards that elicited prediction errors. Participants reappraised their curiosity, allowing us to separate intrinsic motivation from story-driven reward influences. Associations between performance and both pupil diameter and MRI measures of LC integrity supported a role of LC in curiosity regulation. Aging was associated with greater reliance on novelty-driven (initial) curiosity and a shift away from prediction error-related information-seeking. Both age groups showed curiosity-driven memory enhancement, with older adults exhibiting youth-like effects, suggesting a role for intrinsic motivation in preserving cognitive function in aging.

Identifiers

PMID40950154
PMCPMC12424651

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.