Evidence map›Paper›PMID 40950146›Full record

ArticlebioRxiv : the preprint server for biology2025

Mitfa-Independent Melanocyte Progenitors are Highly Susceptible to GNAQ-induced Uveal Melanoma in Adult Zebrafish.

Julius I Yevdash, Delaney Robinson, Rachel Moore, Zhijie Li, Katelyn R Campbell-Hanson, Danielle Gutelius, Stephen P G Moore, Dylan Friend, Isaac O'Toole, Collin Montgomery and 7 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Julius I YevdashDepartment of Surgery, College of Medicine, University of Iowa, Iowa City, IA 52242, USA.ORCID 0009-0001-6482-2279
Delaney RobinsonDepartment of Surgery, College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Rachel MooreDepartment of Surgery, College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Zhijie LiDepartment of Surgery, College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Katelyn R Campbell-HansonDepartment of Surgery, College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Danielle GuteliusDepartment of Dermatology, Boston University School of Medicine, Boston, MA, 02118, USA.
Stephen P G MooreDepartment of Dermatology, Boston University School of Medicine, Boston, MA, 02118, USA.
Dylan FriendDepartment of Surgery, College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Isaac O'TooleDepartment of Surgery, College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Collin MontgomeryDepartment of Surgery, College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Jesse D RiordanDepartment of Anatomy & Cell Biology, University of Iowa, Iowa City, IA, 52242, USA.
Adam J DupuyDepartment of Anatomy & Cell Biology, University of Iowa, Iowa City, IA, 52242, USA.ORCID 0000-0002-8561-4911
Robert A CornellDepartment of Oral Health Sciences, University of Washington, School of Dentistry, Seattle, WA, 98195.ORCID 0000-0003-4207-9100
Elaine M BinkleyHolden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA.
Deborah LangDepartment of Dermatology, Boston University School of Medicine, Boston, MA, 02118, USA.
Ronald J WeigelDepartment of Surgery, College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Colin KennyDepartment of Surgery, College of Medicine, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-8926-4413

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Jon C.D. Houtman · 2000 to 2026
$70.0M
University of Iowa Institutional Training Program in Oral Health ResearchT90DE023520 · NIDCR · UNIVERSITY OF IOWA · PI STEVEN M. LEVY · 2013 to 2026
$5.6M
Predoctoral Training in the Pharmacological SciencesT32GM144636 · NIGMS · UNIVERSITY OF IOWA · PI David L. Roman, STEFAN STRACK · 2022 to 2026
$1.9M
NCI NIH HHS P30 CA086862NIDCR NIH HHS T90 DE023520NIGMS NIH HHS T32 GM144636
6 · The paper itself

Abstract

Melanocytes reside in diverse microenvironments that influence their susceptibility to oncogenic transformation, however, studying rare melanoma subsets has been hindered by the lack of suitable animal models. We developed a primary, immune-competent zebrafish model to study uveal melanoma (UM), utilizing choroidal-targeted injection and electroporation of plasmids containing human

Identifiers

PMID40950146
PMCPMC12431003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.