ArticlebioRxiv : the preprint server for biology2025
InsP3R signaling mediates mitochondrial stress-induced longevity through actomyosin-dependent mitochondrial dynamics.
Gaomin Feng, Elizabeth M Ruark, Alexandra G Mulligan, Eric K F Donahue, Anthony Hoang, Brianne Jacquet-Cribe, Li Peng, Kristopher Burkewitz
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
8 authors.
Gaomin FengDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Elizabeth M RuarkDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Alexandra G MulliganDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Eric K F DonahueDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Anthony HoangDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Brianne Jacquet-CribeDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Li PengDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Kristopher BurkewitzDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0001-8531-0566 Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3MShop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6MVanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9MEnhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5MMedical Scientist Training ProgramT32GM152284 · NIGMS · VANDERBILT UNIVERSITY · PI Christopher S. Williams · 2024 to 2026
$4.8MTargeting ER-mitochondrial calcium signaling to promote healthier agingR01AG073354 · NIA · VANDERBILT UNIVERSITY · PI Kristopher Burkewitz · 2022 to 2026
$1.6MTargeting mechanisms of inter-organelle communication to promote healthy agingR00AG052666 · NIA · VANDERBILT UNIVERSITY · PI BURKEWITZ, KRISTOPHER · 2019 to 2021
$726kAcquisition of a Leica high pressure freezer for the cryo-based electron microscopy techniquesS10MH137068 · NIMH · VANDERBILT UNIVERSITY · PI KRYSTOFIAK, EVAN · 2024 to 2024
$489kNCI NIH HHS P30 CA068485NEI NIH HHS P30 EY008126NIA NIH HHS R00 AG052666NIA NIH HHS R01 AG073354NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS U24 DK059637NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM152284NIH HHS P40 OD010440NIMH NIH HHS S10 MH137068
6 · The paper itselfAbstract
Certain forms of mitochondrial impairment confer longevity, while mitochondrial dysfunction arising from aging and disease-associated mutations triggers severe pathogenesis. The adaptive pathways that distinguish benefit from pathology remain unclear. Here we reveal that longevity induced by mitochondrial Complex I/
Identifiers
PMID40950144
PMCPMC12424781
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390