ArticlebioRxiv : the preprint server for biology2025
Early Changes in Respiration and Motor Activity after Spinal Cord Injury Predict Pain-Related Outcomes in Mice.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Spinal cord injuries (SCIs) may lead to the emergence of chronic pain many weeks after injury. Using the thoracic contusion model of SCI-induced neuropathic pain, we investigated whether early changes in mouse respiration or motor activity could predict and differentiate emergent dysfunction with focus on pain. We measured respiratory rate (RR) and movement (motor activity) in freely behaving mice before and at several time points following SCI. We then assessed behavioral signs of pain or thermal dysregulation by testing evoked hindpaw withdrawal responses to mechanical and thermal heating stimuli and temperature preferences at four weeks after injury. For 2-3 days after injury, mice exhibited sharp decreases in movement and RR variability, but these two parameters were uncorrelated within animals. Mice showed signs of mechanical and thermal hypersensitivity and preferences for warmer temperatures four weeks after injury. Interestingly, mice that moved the least 1 day after SCI preferentially underwent hindpaw mechano-sensitivity (
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