Evidence map›Paper›PMID 40950131›Full record

ArticlebioRxiv : the preprint server for biology2025

A physiological microfluidic blood-brain-barrier model for in vitro study of nanoparticle trafficking and accumulation.

Bryan B Nguyen, Neona M Lowe, Sophia Kellogg, Kuan-Wei Huang, Hannah O'Toole, Elizabeth J Hale, Venktesh S Shirure, Bhupinder S Shergill, Steven C George, Randy P Carney

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Bryan B NguyenDepartment of Biomedical Engineering, University of California, Davis, Davis, USA.ORCID 0000-0002-2857-2508
Neona M LoweDepartment of Biomedical Engineering, University of California, Davis, Davis, USA.ORCID 0000-0002-7426-0273
Sophia KelloggDepartment of Biomedical Engineering, University of California, Davis, Davis, USA.
Kuan-Wei HuangDepartment of Biomedical Engineering, University of California, Davis, Davis, USA.ORCID 0000-0002-1937-645X
Hannah O'TooleDepartment of Biomedical Engineering, University of California, Davis, Davis, USA.ORCID 0000-0002-1843-9332
Elizabeth J HaleDepartment of Biomedical Engineering, University of California, Davis, Davis, USA.ORCID 0009-0006-5273-8834
Venktesh S ShirureDepartment of Biomedical Engineering, University of California, Davis, Davis, USA.ORCID 0000-0002-4430-2612
Bhupinder S ShergillDepartment of Biomedical Engineering, University of California, Davis, Davis, USA.ORCID 0000-0002-7850-0000
Steven C GeorgeDepartment of Biomedical Engineering, University of California, Davis, Davis, USA.ORCID 0000-0003-2263-1914
Randy P CarneyDepartment of Biomedical Engineering, University of California, Davis, Davis, USA.ORCID 0000-0001-8193-1664

Funding

TRAINING IN COMPARATIVE LUNG BIOLOGY AND MEDICINET32HL007013 · NHLBI · UNIVERSITY OF CALIFORNIA DAVIS · PI Elena Goncharova, Nicholas J. KENYON · 1985 to 2026
$10.1M
ENVIRONMENTAL TOXICOLOGYT32ES007059 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura S Van Winkle · 1985 to 2026
$7.9M
SERS diagnostics platform for liquid bioapsy analysis of tumor-associated exosomesR01CA241666 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CARNEY, RANDY · 2020 to 2024
$2.5M
Bottom-up, high-throughput prototyping of extracellular vesicle mimetics using cell-free synthetic biologyR01EB034279 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Randy Carney, Cheemeng Tan · 2023 to 2026
$2.5M
Homogenized, engineered extracellular vesicles for intracranial targetingR01EB033389 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Randy Carney, Aijun Wang · 2023 to 2026
$2.4M
Training Program in PharmacologyT32GM144303 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Donald M Bers, JOHANNES W HELL · 2022 to 2026
$2.1M
UC Davis Training Program in Chemical BiologyT32GM136597 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SHEILA Sue DAVID, Marie C. Heffern · 2021 to 2026
$1.7M
NCI NIH HHS R01 CA241666NHLBI NIH HHS T32 HL007013NIBIB NIH HHS R01 EB033389NIBIB NIH HHS R01 EB034279NIEHS NIH HHS T32 ES007059NIGMS NIH HHS T32 GM136597NIGMS NIH HHS T32 GM144303
6 · The paper itself

Abstract

Although the blood-brain barrier (BBB) restricts passage of most molecules, various naturally occurring and synthetic nanoparticles are nonetheless found within the brain parenchyma. To study the mechanisms underlying this phenomenon, we developed a microfluidic BBB model (mBBB) using human cerebral microvascular endothelial cells (HCMECs) in direct contact with primary human astrocytes and pericytes within a physiologically relevant extracellular matrix. The horizontal architecture enables high-resolution imaging across the full barrier interface and allows direct assessment of nanoparticle transport and accumulation. This

Indexed as

exosomesextracellular vesiclesliposomesmacropinocytosisnanoplasticsnon-animal modelsreceptor mediated transcytosis

Identifiers

PMID40950131
PMCPMC12424677

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.