Evidence map›Paper›PMID 40950126›Full record

ArticlebioRxiv : the preprint server for biology2025

Ectomesenchymal identity emerges via relief of

Lara C Busby, Jessica R Patrick, Luke W Lyons, Megan L Martik

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Lara C BusbyDepartment of Molecular and Cell Biology, University of California, Berkeley; Berkeley, California, USA.ORCID 0000-0003-0705-1364
Jessica R PatrickDepartment of Molecular and Cell Biology, University of California, Berkeley; Berkeley, California, USA.
Luke W LyonsDepartment of Molecular and Cell Biology, University of California, Berkeley; Berkeley, California, USA.ORCID 0009-0000-9168-8880
Megan L MartikDepartment of Molecular and Cell Biology, University of California, Berkeley; Berkeley, California, USA.ORCID 0000-0003-1186-4085

Funding

Reactivating regulatory programs for regenerationDP2HL173858 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Megan Lee Martik · 2023 to 2026
$2.4M
Investigating the contributions of neural crest to adult regenerationR00HD100587 · NICHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI MARTIK, MEGAN LEE · 2021 to 2023
$747k
NHLBI NIH HHS DP2 HL173858NICHD NIH HHS R00 HD100587
6 · The paper itself

Abstract

During vertebrate development, cranial neural crest cells (CNCCs) differentiate into a variety of derivatives, including ectodermal cell types (neurons, glia, and pigment cells) as well as a suite of derivatives that are classically associated with the mesoderm (cartilage, bone and muscle) and are collectively termed 'ectomesenchyme'. While the molecular decisions that guide CNCCs toward ectomesenchymal identity remain incompletely understood, the transcription factor Twist1 plays a central role. Here, we investigate the regulation of

Identifiers

PMID40950126
PMCPMC12424784

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.