Evidence map›Paper›PMID 40950095›Full record

ArticlebioRxiv : the preprint server for biology2025

Hepatocyte FAM210A deficiency disrupts mitochondrial function and triggers juvenile steatosis with compensatory repair in adulthood.

Yubo Wang, Leah Chu, Yumei Zhou, Zihao Jin, Kyoungrae Kim, Katie Heiden, Miguel A Gutierrez-Monreal, Junxiao Ren, Yufen Li, Zhiyong Cheng and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yubo WangDepartment of Animal Sciences, University of Florida, Gainesville, FL 32611, USA.
Leah ChuDepartment of Animal Sciences, University of Florida, Gainesville, FL 32611, USA.
Yumei ZhouDepartment of Animal Sciences, University of Florida, Gainesville, FL 32611, USA.
Zihao JinDepartment of Animal Sciences, University of Florida, Gainesville, FL 32611, USA.
Kyoungrae KimDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA.
Katie HeidenDepartment of Chemistry, University of Florida, Gainesville, FL 32611, USA.
Miguel A Gutierrez-MonrealDepartment of Physiology and Aging, University of Florida, Gainesville, FL 32611, USA.
Junxiao RenDepartment of Animal Sciences, University of Florida, Gainesville, FL 32611, USA.
Yufen LiDepartment of Animal Sciences, University of Florida, Gainesville, FL 32611, USA.
Zhiyong ChengFood Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA.
Kari B BassoDepartment of Chemistry, University of Florida, Gainesville, FL 32611, USA.
Karyn A EsserDepartment of Physiology and Aging, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0002-5791-1441
Terence E RyanDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0003-0780-029X
Feng YueDepartment of Animal Sciences, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0002-5856-3506

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Stephen D Anton · 2007 to 2026
$22.8M
Regulation of Mitochondrial Remodeling in Adipose ThermogenesisR01DK136722 · NIDDK · UNIVERSITY OF FLORIDA · PI Feng Yue · 2023 to 2026
$1.8M
Acquisition of timsTOF Pro for Complex Lipidomic AnalysesS10OD030250 · OD · UNIVERSITY OF FLORIDA · PI BASSO, KARI B · 2022 to 2022
$658k
Acquisition of a Q Exactive HF Hybrid Quadrupole-OrbitrapS10OD021758 · OD · UNIVERSITY OF FLORIDA · PI BASSO, KARI B · 2017 to 2017
$600k
NIA NIH HHS P30 AG028740NIDDK NIH HHS R01 DK136722NIH HHS S10 OD021758NIH HHS S10 OD030250
6 · The paper itself

Abstract

Mitochondrial dynamics are central to maintaining liver metabolic homeostasis, yet the mechanisms that safeguarding mitochondrial integrity during development and metabolic dysfunction remain poorly defined. Here, we identify Family with sequence similarity 210 member A (FAM210A) as a hepatocyte-enriched mitochondrial regulator essential for postnatal liver maturation. Hepatocyte-specific deletion of

Indexed as

Adaptive stress responseFAM210AHepatocyteLiver repairMitochondriaSteatosis

Identifiers

PMID40950095
PMCPMC12424863

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.