Evidence map›Paper›PMID 40950078›Full record

ArticlebioRxiv : the preprint server for biology2025

Calorie Restriction modulates beta cell IP

Johannes Pfabe, Cristiane Dos Santos, Melanie Cutler, Christopher Acree, Aliyah Habashy, Amanda Cambraia, Guy Perkins, Mark H Ellisman, Marjan Slak Rupnik, Rafael Arrojo E Drigo

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Johannes PfabeInstitute of Physiology, Center for Physiology and Pharmacology and Comprehensive Center for AI in Medicine, Medical University of Vienna, Austria 1090.
Cristiane Dos SantosDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA 37211.ORCID 0000-0002-6859-3784
Melanie CutlerDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA 37211.ORCID 0009-0008-0315-8643
Christopher AcreeDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA 37211.
Aliyah HabashyDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA 37211.
Amanda CambraiaDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA 37211.ORCID 0000-0002-0017-9966
Guy PerkinsNational Center for Imaging and Microscopy Research (NCMIR) and the Department of Neurosciences, University of California San Diego, School of Medicine, La Jolla, California, 92135.ORCID 0000-0002-1834-6646
Mark H EllismanNational Center for Imaging and Microscopy Research (NCMIR) and the Department of Neurosciences, University of California San Diego, School of Medicine, La Jolla, California, 92135.ORCID 0000-0001-8893-8455
Marjan Slak RupnikInstitute of Physiology, Center for Physiology and Pharmacology and Comprehensive Center for AI in Medicine, Medical University of Vienna, Austria 1090.ORCID 0000-0002-3744-4882
Rafael Arrojo E DrigoDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA 37211.ORCID 0000-0001-7712-013X

Funding

National Center for Microscopy and Imaging Research: A BRAIN Technology Integration and Dissemination ResourceU24NS120055 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2021 to 2025
$5.4M
Control of beta cell function and survival by RYR2-mediated calcium signalsR01DK127236 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI EVANS-MOLINA, CARMELLA · 2021 to 2025
$2.2M
Beta cell adaptation mechanisms during caloric restriction and ER stressR01DK138141 · NIDDK · VANDERBILT UNIVERSITY · PI Rafael Arrojo e Drigo · 2024 to 2026
$1.5M
NIDDK NIH HHS R01 DK127236NIDDK NIH HHS R01 DK138141NINDS NIH HHS U24 NS120055
6 · The paper itself

Abstract

Calorie restriction (CR) promotes beta cell longevity by regulating cell identity, organelle and protein homeostasis, and metabolism pathways. CR beta cells have higher cAMP levels and mitochondria with an elevated potential to generate ATP. However, CR beta cells have reduced insulin secretion due to increased peripheral insulin sensitivity. How CR impacts beta cell Ca

Indexed as

beta cell calciumcalorie restrictionendoplasmic reticulum (ER)

Identifiers

PMID40950078
PMCPMC12424983

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.