Evidence map›Paper›PMID 40950066›Full record

ArticlebioRxiv : the preprint server for biology2025

The

Alexander Paredes, Chioma Iheacho, Kelly N Chacón, Aaron T Smith

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Alexander ParedesDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland, 21250 USA.
Chioma IheachoDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland, 21250 USA.
Kelly N ChacónDepartment of Chemistry, Reed College, Portland, Oregon, 97202 USA.ORCID 0000-0003-1332-7283
Aaron T SmithDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland, 21250 USA.ORCID 0000-0002-9332-8683

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Aina E. Cohen, KEITH O HODGSON · 2020 to 2026
$43.3M
Deciphering the Mechanisms of Pathogenic Ferrous Iron Acquisition and Eukaryotic Post-Translational ArginylationR35GM133497 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI Aaron T Smith · 2019 to 2026
$2.9M
Graduate Training at The Chemistry Biology InterfaceT32GM158458 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI Steven Fletcher, Aaron T Smith · 2025 to 2026
$564k
NIGMS NIH HHS P30 GM133894NIGMS NIH HHS R35 GM133497NIGMS NIH HHS T32 GM158458
6 · The paper itself

Abstract

Prokaryotic two-component signal transduction systems (TCSs) are widely utilized by bacteria to respond to their environment and are typically composed of a transmembrane sensor His kinase (HK) and a cytosolic DNA-binding response regulator (RR) that work together to respond to environmental stimuli. An important TCS that regulates the expression of genes involved in biofilm formation and antibiotic resistance in many pathogens is the BqsRS/CarRS system, originally identified in

Indexed as

biofilmsironkinasemetalloproteinssignal transductiontwo-component system

Identifiers

PMID40950066
PMCPMC12424716

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.