Evidence map›Paper›PMID 40950059›Full record

ArticlebioRxiv : the preprint server for biology2025

Validation and Optimization of Breeding Strategy for miR-141/200c Knockout Mice to Eliminate Off-Target Gene Silencing using FLPo Deleter.

Rashmi Srivastava, Sanjeev Kumar Yadav, Mary-Catherine Cormier, Katie Lowther, Siu-Pok Yee, Rajkumar Verma

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Rashmi SrivastavaDepartment of Neurosciences, UConn Health Farmington CT 06030.ORCID 0000-0002-8773-3973
Sanjeev Kumar YadavDepartment of Neurosciences, UConn Health Farmington CT 06030.ORCID 0000-0002-4136-2011
Mary-Catherine CormierDepartment of Neurosciences, UConn Health Farmington CT 06030.
Katie LowtherCenter for Mouse Genome Modification, UConn Health, Farmington CT 06030.
Siu-Pok YeeCenter for Mouse Genome Modification, UConn Health, Farmington CT 06030.
Rajkumar VermaDepartment of Neurosciences, UConn Health Farmington CT 06030.

Funding

Developing next-generation RNA inhibitors for stroke therapyR01NS140176 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Raman Bahal, Rajkumar Verma · 2025 to 2026
$1.0M
Next generation gamma Peptide Nucleic Acids (yPNAs) for the treatment of ischemic strokeR21NS114981 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI VERMA, RAJKUMAR · 2020 to 2020
$464k
NINDS NIH HHS R01 NS140176NINDS NIH HHS R21 NS114981
6 · The paper itself

Abstract

MicroRNAs (miRNAs) of the miR-200 family specifically miR-141 and miR-200c regulate neurogenesis, differentiation, and epithelial-mesenchymal transitions in development and several diseases including cancer and stroke. The STOCK Mirc13

Identifiers

PMID40950059
PMCPMC12424681

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.