Evidence map›Paper›PMID 40950053›Full record

ArticlebioRxiv : the preprint server for biology2025

Sex differences in the developing human cortex intersect with genetic risk of neurodevelopmental disorders.

Kelsey Hennick, Yang Sui, Druha Karunakaran, Ally Nicollela, Rachel Leonard, Rebecca Meyer-Schuman, Hanna Berk-Rauch, Tianyun Wang, Aravinda Chakravarti, Huda Y Zoghbi and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. What goes down may come up: regurgitative behaviors and their underlying gut-brain axes-insights from genetic models and related pathologies.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kelsey HennickDepartment of Neurological Surgery, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-6127-2400
Yang SuiDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
Druha KarunakaranCenter for Human Genetics and Genomics, New York University Grossman School of Medicine, New York, NY 10016,USA.
Ally NicollelaDepartment of Neurological Surgery, University of California, San Francisco, CA 94143, USA.
Rachel LeonardDepartment of Neurological Surgery, University of California, San Francisco, CA 94143, USA.
Rebecca Meyer-SchumanDepartment of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Hanna Berk-RauchCenter for Human Genetics and Genomics, New York University Grossman School of Medicine, New York, NY 10016,USA.
Tianyun WangDepartment of Medical Genetics, Center for Medical Genetics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.
Aravinda ChakravartiCenter for Human Genetics and Genomics, New York University Grossman School of Medicine, New York, NY 10016,USA.
Huda Y ZoghbiDepartment of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Evan E EichlerDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0002-8246-4014
Tomasz J NowakowskiDepartment of Neurological Surgery, University of California, San Francisco, CA 94143, USA.

Funding

Sporadic Mutations and Autism Spectrum DisordersR01MH101221 · NIMH · UNIVERSITY OF WASHINGTON · PI EICHLER, EVAN · 2013 to 2025
$9.2M
Assessing Genomic, Regulatory and Transcriptional Variation at Single Nuclei Resolution in the Brains of Individuals with Autism Spectrum DisorderR01MH125516 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ARNOLD KRIEGSTEIN, Tomasz Nowakowski · 2021 to 2026
$3.8M
Developmental Timing During Cortical DevelopmentR01NS123263 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Tomasz Nowakowski · 2022 to 2026
$2.1M
NIMH NIH HHS R01 MH101221NIMH NIH HHS R01 MH125516NINDS NIH HHS R01 NS123263
6 · The paper itself

Abstract

Autism is highly heritable and diagnosed more frequently in males than females. To identify neurodevelopmental processes that might present sex-biased vulnerability, we generated transcriptomic and epigenomic profiles of cell types present in the prenatally developing human cerebral cortex of 27 males and 21 females. By intersecting sex-biased molecular signatures and genes with

Indexed as

autismgeneticshuman cortexneurodevelopmental disordersSex differences

Identifiers

PMID40950053
PMCPMC12424995

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.