Evidence map›Paper›PMID 40950050›Full record

ArticlebioRxiv : the preprint server for biology2025

Aminopeptidase N is a receptor for hedgehog merbecoviruses.

Min Jin, Victoria A Jefferson, Zhe Zhao, Nicholas J Catanzaro, Luca De Sabato, Emma L Keller, Bridget L Menasche, Cameron Hoffman, Anna Castelli, Ilaria Di Bartolo and 13 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Min JinDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Victoria A JeffersonPaul G. Allen School for Global Health, Washington State University, Pullman, WA.
Zhe ZhaoDepartments of Laboratory Medicine and Immunobiology, Yale University, New Haven, CT.
Nicholas J CatanzaroDepartment of Epidemiology, Gillings School of Global Public Heath, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Luca De SabatoDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Emma L KellerDepartments of Laboratory Medicine and Immunobiology, Yale University, New Haven, CT.
Bridget L MenascheDepartments of Laboratory Medicine and Immunobiology, Yale University, New Haven, CT.
Cameron HoffmanDepartment of Epidemiology, Gillings School of Global Public Heath, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Anna CastelliIstituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER) - Virology Department, Via A. Bianchi, 9, 25124 Brescia, Italy.
Ilaria Di BartoloDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Gabriele VaccariDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Tyler N StarrDepartment of Biochemistry, University of Utah, Salt Lake City, UT.
Stephanie N SeifertDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Adrian A CastellanosCary Institute of Ecosystem Studies, Millbrook, NY.
Barbara A HanCary Institute of Ecosystem Studies, Millbrook, NY.
Leonid SerebryannyyVaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Alicen B SpauldingVaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Daniel C DouekVaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Ana MorenoIstituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER) - Virology Department, Via A. Bianchi, 9, 25124 Brescia, Italy.
Ralph S BaricDepartment of Epidemiology, Gillings School of Global Public Heath, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Craig B WilenDepartments of Laboratory Medicine and Immunobiology, Yale University, New Haven, CT.
James M RiniDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Michael LetkoPaul G. Allen School for Global Health, Washington State University, Pullman, WA.

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00014 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2021 to 2025
$62.6M
Structure-based design of broadly protective coronavirus vaccinesP01AI167966 · NIAID · UNIVERSITY OF WASHINGTON · PI BALI PULENDRAN · 2022 to 2026
$15.3M
Infectious Diseases and Microbial Immunology Training ProgramT32AI007025 · NIAID · WASHINGTON STATE UNIVERSITY · PI Thomas H KAWULA, M KARIUKI NJENGA · 1985 to 2026
$7.4M
Functional Viromics of Betacoronavirus EntryR01AI179720 · NIAID · WASHINGTON STATE UNIVERSITY · PI Barbara A. Han, Michael Letko · 2024 to 2026
$1.1M
NIAID NIH HHS P01 AI167966NIAID NIH HHS R01 AI179720NIAID NIH HHS T32 AI007025NIH HHS 75N93021C00014
6 · The paper itself

Abstract

Merbecoviruses, closely related to the highly pathogenetic Middle East Respiratory Syndrome Coronavirus (MERS-CoV), circulate in hedgehogs throughout Europe and Asia, raising concerns about zoonotic transmission to humans and domestic animals. Unfortunately, how these viruses enter host cells remains unknown, hindering experimental studies. Here, we tested known coronavirus receptor orthologues from European hedgehogs (

Identifiers

PMID40950050
PMCPMC12425009

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.