Evidence map›Paper›PMID 40950049›Full record

ArticlebioRxiv : the preprint server for biology2025

Computational analysis of therapeutic potential for simplified Piper. spp- derived medicinal mixtures in anxiety, sleep, pain and seizure.

B G Rice, B Wooton, C Jansen, J Howard, J Nixon, L Ellis, A Rogers, C N Adra, A J Stokes, S A Aporosa and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

B G RiceLaboratory of Pharmacology and Analytics, Biology and Data Science Programs, School of Natural Sciences and Mathematics, Chaminade University, Honolulu, Hawai'i.ORCID 0009-0006-7360-937X
B WootonLaboratory of Pharmacology and Analytics, Biology and Data Science Programs, School of Natural Sciences and Mathematics, Chaminade University, Honolulu, Hawai'i.
C JansenLaboratory of Pharmacology and Analytics, Biology and Data Science Programs, School of Natural Sciences and Mathematics, Chaminade University, Honolulu, Hawai'i.ORCID 0000-0002-1579-8938
J HowardLaboratory of Pharmacology and Analytics, Biology and Data Science Programs, School of Natural Sciences and Mathematics, Chaminade University, Honolulu, Hawai'i.ORCID 0009-0001-0457-025X
J NixonNational Research Council of Canada, Halifax, Nova Scotia, Canada.
L EllisNational Research Council of Canada, Halifax, Nova Scotia, Canada.
A RogersGBS Global Biopharma, Ottawa, Canada.
C N AdraThe Adra Institute, Boston, Massachusetts.ORCID 0000-0002-4132-4621
A J StokesLaboratory of Experimental Medicine, Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii.ORCID 0000-0002-3526-4685
S A AporosaTe Huataki Waiora School of Health and Te Kura Whatu Oho Mauri School of Psychology, University of Waikato, Hamilton, Aotearoa New Zealand.ORCID 0000-0002-4490-9545
A L Small-HowardGBS Global Biopharma, Ottawa, Canada.ORCID 0000-0001-9392-7443
H TurnerLaboratory of Pharmacology and Analytics, Biology and Data Science Programs, School of Natural Sciences and Mathematics, Chaminade University, Honolulu, Hawai'i.ORCID 0000-0002-9629-7691

Funding

AIM-AHEAD Coordinating Center - All Four CoresOT2OD032581 · OD · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI Paul Avillach, Bettina M. Beech · 2021 to 2026
$168.7M
UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI HELEN C TURNER · 2012 to 2026
$60.3M
Cannabinoid and terpene regulation of nocioception and peripheral sensitization through ionotropic receptorsR15DA051749 · NIDA · CHAMINADE UNIVERSITY OF HONOLULU · PI TURNER, HELEN C · 2020 to 2020
$433k
NIDA NIH HHS R15 DA051749NIGMS NIH HHS P20 GM103466NIH HHS OT2 OD032581
6 · The paper itself

Abstract

Phytomedicines have played a vital role in traditional medical systems globally, particularly in providing culturally relevant and accessible healthcare solutions.

Indexed as

anxietyKavaPiperPTSDsleeptraditional medicine

Identifiers

PMID40950049
PMCPMC12424840

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.