Evidence map›Paper›PMID 40950042›Full record

ArticlebioRxiv : the preprint server for biology2025

Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Autophagy and Mitophagy.

Asli E Atici, Prasant K Jena, Thacyana T Carvalho, Benjamin L Ross, Emily A Aubuchon, Malcolm E Lane, Angela C Gomez, Youngho Lee, Shuang Chen, Timothy R Crother and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Asli E AticiDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Cedars-Sinai Health Sciences University, Los Angeles, CA, USA.
Prasant K JenaDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Cedars-Sinai Health Sciences University, Los Angeles, CA, USA.
Thacyana T CarvalhoDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Cedars-Sinai Health Sciences University, Los Angeles, CA, USA.
Benjamin L RossDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Cedars-Sinai Health Sciences University, Los Angeles, CA, USA.
Emily A AubuchonDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Cedars-Sinai Health Sciences University, Los Angeles, CA, USA.
Malcolm E LaneDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Cedars-Sinai Health Sciences University, Los Angeles, CA, USA.
Angela C GomezDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Cedars-Sinai Health Sciences University, Los Angeles, CA, USA.
Youngho LeeDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Cedars-Sinai Health Sciences University, Los Angeles, CA, USA.
Shuang ChenDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Cedars-Sinai Health Sciences University, Los Angeles, CA, USA.
Timothy R CrotherDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Cedars-Sinai Health Sciences University, Los Angeles, CA, USA.
Moshe ArditiDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Cedars-Sinai Health Sciences University, Los Angeles, CA, USA.
Magali Noval RivasDepartment of Pediatrics, Cedars-Sinai Guerin Children's, Cedars-Sinai Health Sciences University, Los Angeles, CA, USA.

Funding

Role of intestinal microbiome and gut permeability in the development of Kawasaki Disease vasculitisR01HL139766 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Magali Noval Rivas · 2018 to 2026
$3.4M
Role of neutrophils and eosinophils in bacterial ligand-induced vasculitisR01AI157274 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI ARDITI, MOSHE, NOVAL RIVAS, MAGALI · 2020 to 2024
$3.2M
RNA-Mediated Inter-Organelle Communication in AtherosclerosisR01HL149972 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI ARDITI, MOSHE · 2020 to 2023
$2.0M
Role of Sex in Immune Stromal cell Interactions driving cardiovascular lesions in Kawasaki Disease vasculitisR01HL170580 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Moshe Arditi · 2024 to 2026
$1.7M
Targeting the Sirt-1 pathway to modulate inflammation during murine Kawasaki Disease vasculitisR01HL159297 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI NOVAL RIVAS, MAGALI · 2021 to 2024
$1.7M
NHLBI NIH HHS R01 HL139766NHLBI NIH HHS R01 HL149972NHLBI NIH HHS R01 HL159297NHLBI NIH HHS R01 HL170580NIAID NIH HHS R01 AI157274
6 · The paper itself

Abstract

backgroundSirtuin 1 (SIRT1), a NAD

methodsUsing the

resultsSIRT1 expression was downregulated in cardiovascular lesions of LCWE-injected mice, which was associated with a significant reduction of circulating levels of nicotinamide. Supplementation of mice with NAD

conclusionsThis study reveals the presence of an impaired NAD

Identifiers

PMID40950042
PMCPMC12424839

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.