Evidence map›Paper›PMID 40949983›Full record

ArticlebioRxiv : the preprint server for biology2025

A Spinal Circuit for Modular Gating of Organ Somatosensation.

Yufen Zhang, Fang Liu, Lite Yang, Hannah J Hahm, Monique R Heitmeier, Takao Okuda, Masahiro Kawatani, Jahnia T Harrigan, Erica C Morrison-Rodriguez, Anna Petukhova and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yufen ZhangDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, United States.ORCID 0000-0003-3306-4193
Fang LiuDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, United States.ORCID 0009-0007-2310-9008
Lite YangDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, United States.ORCID 0000-0002-3647-6073
Hannah J HahmDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, United States.ORCID 0009-0008-1851-7426
Monique R HeitmeierDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, United States.
Takao OkudaDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, United States.
Masahiro KawataniDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, United States.ORCID 0000-0002-0303-5650
Jahnia T HarriganDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, United States.
Erica C Morrison-RodriguezDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, United States.
Anna PetukhovaDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, United States.
Zhaotong LuDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, United States.
Harry A HeitmeierDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, United States.
Vijay K SamineniDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, United States.ORCID 0000-0002-9491-2793

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
Neural Mechanisms Underlying IC/BPSR01DK128475 · NIDDK · WASHINGTON UNIVERSITY · PI SAMINENI, VIJAY K · 2021 to 2025
$2.3M
Spinal Mechanisms Underlying Interstitial Cystitis/Bladder Pain Syndromes (IC/BPS)R01DK139386 · NIDDK · WASHINGTON UNIVERSITY · PI Vijay K Samineni · 2024 to 2026
$2.0M
Elucidating Roles of Distinct Spinal Cord Cell types in Mediating Interstitial Cystitis (IC)/Bladder Pain Syndrome (BPS)R01DK140445 · NIDDK · WASHINGTON UNIVERSITY · PI Vijay K Samineni · 2024 to 2026
$1.9M
DEFINING THE NEURAL BASIS FOR CHRONIC BLADDER PAIN AND ITS ASSOCIATED COMORBID DISORDERSK01DK115634 · NIDDK · WASHINGTON UNIVERSITY · PI SAMINENI, VIJAY K · 2018 to 2022
$582k
NCI NIH HHS P30 CA091842NIDDK NIH HHS K01 DK115634NIDDK NIH HHS R01 DK128475NIDDK NIH HHS R01 DK139386NIDDK NIH HHS R01 DK140445
6 · The paper itself

Abstract

End-organs such as the bladder rely on a delicate balance between internal urgency and voluntary restraint. However, the specific spinal circuits coordinating these functions remain poorly defined. Here, we identify a genetically defined population of lumbosacral spinal interneurons marked by

Identifiers

PMID40949983
PMCPMC12425005

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.