Evidence map›Paper›PMID 40949982›Full record

ArticlebioRxiv : the preprint server for biology2025

NAT10 Suppresses RNA Sensing Induced IFN-β Transactivation to Promote Viral Infection via Interfering with IRF3 Activities.

Youngmin Park, Jinshan He, Eleya Suha, Wu Zhenyu, Guillaume N Fiches, Dawei Zhou, Emily G Watters, Zhixian M He, Kateepe Asn Shanaka, Thurbu T Lepcha and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Identification of the Role ofVeterinary sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Youngmin ParkDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Jinshan HeDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Eleya SuhaDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Wu ZhenyuDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Guillaume N FichesDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Dawei ZhouDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Emily G WattersDepartment of Microbiology, College of Arts and Sciences, The Ohio State University, Columbus, OH 43210, USA.
Zhixian M HeDepartment of Microbiology, College of Arts and Sciences, The Ohio State University, Columbus, OH 43210, USA.
Kateepe Asn ShanakaDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Thurbu T LepchaDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Yan LiuDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Netty G SantosoDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Jian ZhuDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.

Funding

Investigate Host Gene Isoforms Contributing to HIV Persistence in Cocaine UsersR01DA059538 · NIDA · OHIO STATE UNIVERSITY · PI Wei Jiang, Jian Zhu · 2023 to 2026
$2.9M
Target Host Epigenetic Regulation of HIV Proviruses to Reinforce Viral Deep Latency in MicrogliaR01MH134402 · NIMH · OHIO STATE UNIVERSITY · PI HO, WENZHE, ZHU, JIAN · 2023 to 2025
$2.2M
(PQ4) Role of HIV-induced PLK1 Activation in Regulation of gamma-Herpesvirus Reservoirs in LymphocytesR01CA260690 · NCI · OHIO STATE UNIVERSITY · PI SANTOSO, NETTY G · 2021 to 2025
$1.9M
Antagonize Host Survival and Immune Escape Mechanisms for Elimination of HIV Viral ReservoirsR56AI181631 · NIAID · OHIO STATE UNIVERSITY · PI LING, BINHUA "JULIE", ZHU, JIAN · 2024 to 2024
$842k
NCI NIH HHS R01 CA260690NIAID NIH HHS R56 AI181631NIDA NIH HHS R01 DA059538NIMH NIH HHS R01 MH134402
6 · The paper itself

Abstract

Cells can sense invading viruses and trigger type I interferons (IFN-α/β) to evoke antiviral innate immune response. Induction of IFNs needs to be fine-tuned to achieve the antiviral consequence while avoiding severe disruption of host cell homeostasis. Here, we reported that NAT10, the acetyltransferase of histone and N4-acetylcytidine (ac4C) RNA modification, promotes infection of RNA viruses via regulation of type I IFN signaling. Depletion of NAT10 increased the expression of IFN-β and interferon-stimulated genes (ISGs) upon stimulation of type I IFN antiviral signaling, while it impaired viral replication. NAT10 dynamically associated with the IFN-β promotor and negatively regulated IRF3 through modulation of long non-coding RNAs (lncRNAs) that inhibit IRFs. Consistently, the small molecule inhibitor of NAT10, Remodelin, increased IFN-β expression while inhibiting viral infections. Overall, our findings indicated that NAT10 is a negative regulator of type I IFN signaling, suggesting its potential as a target of antiviral treatment.

Indexed as

antiviralimmune signalinginterferonIRF3NAT10remodelinvirus

Identifiers

PMID40949982
PMCPMC12424707

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.