Evidence map›Paper›PMID 40949975›Full record

ArticlebioRxiv : the preprint server for biology2025

An Inflammatory and Quiescent HSC Subpopulation Expands with Age in Humans.

Ksenia R Safina, Dylan A Kotliar, Michelle Curtis, Jonathan D Good, Chen Weng, Shawn David, Soumya Raychaudhuri, Antonia Kreso, Jennifer Trowbridge, Vijay G Sankaran and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Ksenia R SafinaDivision of Hematology, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-5126-9953
Dylan A KotliarBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Michelle CurtisBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Jonathan D GoodDivision of Hematology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Chen WengDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Shawn DavidThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Soumya RaychaudhuriBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-1901-8265
Antonia KresoBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Jennifer TrowbridgeThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Vijay G SankaranBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0003-0044-443X
Peter van GalenDivision of Hematology, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-0735-1570

Funding

Systematic Genetic Dissection of Human ErythropoiesisR01DK103794 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI Vijay Ganesh Sankaran · 2014 to 2026
$5.9M
Next generation functional genomics of hematology traitsR01HL146500 · NHLBI · UNIVERSITY OF WASHINGTON · PI ALEXANDER P REINER · 2020 to 2026
$5.7M
Developing Effective Approaches to Extend Hematopoietic Healthspan by Targeting Cell-Extrinsic and Cell-Intrinsic Alterations at Middle AgeR01DK118072 · NIDDK · JACKSON LABORATORY · PI Jennifer Jean Trowbridge · 2018 to 2026
$4.2M
Inflammatory Signaling in DNMT3A-Mutated Human Hematopoietic Stem CellsU01AG077925 · NIA · JACKSON LABORATORY · PI LEVINE, ROSS L, TROWBRIDGE, JENNIFER JEAN · 2021 to 2025
$2.9M
Selective pressures from inherited variation impacting myeloproliferative neoplasm initiationR01CA265726 · NCI · BOSTON CHILDREN'S HOSPITAL · PI Vijay Ganesh Sankaran · 2022 to 2026
$2.5M
Discovery of Aging-Associated Mechanisms Causing Expansion and Progression of Clonal Hematopoiesis of Indeterminant Potential (CHIP)R01AG069010 · NIA · JACKSON LABORATORY · PI TROWBRIDGE, JENNIFER JEAN · 2020 to 2024
$2.4M
Variant to Function Mapping of B-ALL Risk LociR01CA292941 · NCI · BOSTON CHILDREN'S HOSPITAL · PI Adam De Smith, Vijay Ganesh Sankaran · 2024 to 2026
$2.0M
Clonal analysis of cancer by mitochondrial DNA barcodingR33CA278393 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI SANKARAN, VIJAY GANESH, VAN GALEN, PETER · 2023 to 2025
$1.3M
Deciphering Determinants of Somatic Evolution with Single-Cell GenealogyK99HG013991 · NHGRI · BOSTON CHILDREN'S HOSPITAL · PI Chen Weng · 2025 to 2026
$254k
NCI NIH HHS R01 CA265726NCI NIH HHS R01 CA292941NCI NIH HHS R33 CA278393NHGRI NIH HHS K99 HG013991NHLBI NIH HHS R01 HL146500NIA NIH HHS R01 AG069010NIA NIH HHS U01 AG077925NIDDK NIH HHS R01 DK103794NIDDK NIH HHS R01 DK118072
6 · The paper itself

Abstract

Aging of the blood system impacts systemic health and can be traced to hematopoietic stem cells (HSCs). Despite multiple reports on human HSC aging, a unified map detailing their molecular age-related changes is lacking. We developed a consensus map of gene expression in HSCs by integrating seven single-cell datasets. This map revealed previously unappreciated heterogeneity within the HSC population. It also links inflammatory pathway activation (TNF/NFκB, AP-1) and quiescence within a single gene expression program. This program dominates an inflammatory HSC subpopulation that increases with age, highlighting a potential target for further experimental studies and anti-aging interventions.

Identifiers

PMID40949975
PMCPMC12424952

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.