ArticlebioRxiv : the preprint server for biology2025
Spatial Single-Cell Atlas Reveals KSHV-Driven Broad Cellular Reprogramming, Progenitor Expansion, Immune and Vascular Remodeling in Kaposi's Sarcoma.
Wen Meng, Arun Das, Harsh Sinha, Rana Naous, Paige M Bracci, Mike McGrath, Yufei Huang, Shou-Jiang Gao
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Wen MengCancer Virology Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Arun DasCancer Virology Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Harsh SinhaCancer Virology Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Rana NaousDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Paige M BracciDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Mike McGrathDepartment of Medicine, The University of California at San Francisco, San Francisco, California, USA.
Yufei HuangCancer Virology Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Shou-Jiang GaoCancer Virology Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Funding
VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0MCell Model for KSHV Infection and Genetic ManipulationR01CA096512 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Shou-Jiang Gao · 2003 to 2026
$7.4MRegulation of KSHV replication by N6-methyladenosine (m6A) - Diversity SupplementR01CA124332 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GAO, SHOU-JIANG · 2007 to 2025
$5.0MImpact of microbiota on AIDS-Kaposi’s sarcoma development and therapyR01CA284554 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Shou-Jiang Gao · 2023 to 2026
$3.1MCitrulline-urea cycle in KSHV cellular transformationR01CA278812 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Shou-Jiang Gao · 2023 to 2026
$2.1Mm6A-suite: an informatics pipeline and resource for elucidating roles of m6A epitranscriptome in cancerU01CA279618 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HUANG, YUFEI · 2023 to 2025
$1.8MMETTL16 and S-adenosylmethionine cycle in KSHV infectionR01CA291244 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Shou-Jiang Gao · 2025 to 2026
$1.3MHigh-Throughput Computing for Genomics and Bioinformatics ResearchS10OD028483 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEE, ADRIAN V · 2021 to 2021
$574kNovel geometric deep learning models for tissue structure-aware spatial expression representations from spatially resolved single-cell transcriptomics dataR21GM155774 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAO, SHOU-JIANG, HUANG, YUFEI · 2024 to 2025
$433kNCI NIH HHS P30 CA047904NCI NIH HHS R01 CA096512NCI NIH HHS R01 CA124332NCI NIH HHS R01 CA278812NCI NIH HHS R01 CA284554NCI NIH HHS R01 CA291244NCI NIH HHS U01 CA279618NIGMS NIH HHS R21 GM155774NIH HHS S10 OD028483
6 · The paper itselfAbstract
Kaposi's sarcoma (KS) is a highly inflammatory, angiogenic tumor driven by Kaposi's sarcoma-associated herpesvirus (KSHV), yet the origins of tumor cells and mechanisms of progression remain unclear. Here, we present the first spatial single-cell atlas of KS, profiling 256 samples across patch, plaque, and nodular lesions and normal controls. We identify CD34
Indexed as
CD34+ Progenitor CellsEndothelial PlasticityImmune ModulationKaposi’s SarcomaKaposi’s Sarcoma-Associated HerpesvirusKSKSHVLECsLymphatic Endothelial CellsscSRTSingle-Cell Spatially Resolved TranscriptomicsTAMsTMETumor-Associated MacrophagesTumor Cell OriginTumor MicroenvironmentTumor Niches
Identifiers
PMID40949967
PMCPMC12424991
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