Evidence map›Paper›PMID 40949951›Full record

ArticlebioRxiv : the preprint server for biology2025

Germline stem cell isolation, lineage tracing, and aging in a protochordate.

Tom Levy, Chiara Anselmi, Katherine J Ishizuka, Tal Gordon, Yotam Voskoboynik, Erin McGeever, Angela M Detweiler, Liron Levin, Karla J Palmeri, Daniel Dan Liu and 11 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Tom LevyInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-1484-0310
Chiara AnselmiInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Katherine J IshizukaInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Tal GordonInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Yotam VoskoboynikDepartment of Bioinformatics and System Biology, Jacobs School of Engineering, University of California San Diego, San Diego, CA, USA.
Erin McGeeverChan Zuckerberg Biohub, San Francisco, CA, USA.
Angela M DetweilerChan Zuckerberg Biohub, San Francisco, CA, USA.
Liron LevinBioinformatics Core Facility, Ilse Katz Institute for Nanoscale Science & Technology, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Karla J PalmeriInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Daniel Dan LiuInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-0100-5973
Rahul SinhaInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Benjamin F Ohene-GambillInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Tal RavehInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Maurizio MorriChan Zuckerberg Biohub, San Francisco, CA, USA.
Virginia VanniDipartimento di Biologia, Università degli Studi di Padova, 35131 Padova, Italy.
Lucia ManniDipartimento di Biologia, Università degli Studi di Padova, 35131 Padova, Italy.
Debashis SahooDepartment of Bioinformatics and System Biology, Jacobs School of Engineering, University of California San Diego, San Diego, CA, USA.ORCID 0000-0003-2329-8228
Norma F NeffChan Zuckerberg Biohub, San Francisco, CA, USA.
Benyamin RosentalThe Shraga Segal Department of Microbiology, Immunology, and Genetics, Faculty of Health Sciences. Center for Regenerative Medicine and Stem Cells. Ben Gurion University of the Negev, Beer Sheva, Israel.
Irving L WeissmanInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Ayelet VoskoboynikInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Funding

Evolutionary Conserved Mechanisms that Control Central Nervous System Development Regeneration and DegenerationR01AG076908 · NIA · STANFORD UNIVERSITY · PI Ayelet Voskoboynik · 2022 to 2026
$1.9M
NIA NIH HHS R01 AG076908
6 · The paper itself

Abstract

Germline stem cells (GSCs), the source of gametes, are the only stem cells capable of passing genes to future generations and are therefore considered units of natural selection. Yet, the factors that influence GSC fitness, and thus govern GSC competition, which exist in both protochordates and mammals, remain poorly understood. We studied how aging affects GSC fitness in the protochordate

Identifiers

PMID40949951
PMCPMC12424747

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.