Evidence map›Paper›PMID 40949946›Full record

ArticlebioRxiv : the preprint server for biology2025

Structural basis for loading of Transcription Repair-Coupling factor Mfd onto stalled elongation complexes.

Joshua Brewer, Eliza Llewellyn, James Chen, Elizabeth A Campbell, Seth A Darst

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Joshua BrewerLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065.ORCID 0000-0002-6737-7828
Eliza LlewellynLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065.
James ChenLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065.
Elizabeth A CampbellLaboratory of Molecular Pathogenesis, The Rockefeller University, New York, NY 10065.ORCID 0000-0002-2009-4177
Seth A DarstLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065.ORCID 0000-0002-8241-3153

Funding

NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
TRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7M
Structure, function, and regulation of the bacterial transcription cycleR35GM118130 · NIGMS · ROCKEFELLER UNIVERSITY · PI DARST, SETH A. · 2016 to 2025
$8.9M
NIGMS NIH HHS P41 GM103310NIGMS NIH HHS R35 GM118130NIGMS NIH HHS U24 GM129539
6 · The paper itself

Abstract

Transcription-coupled repair (TCR) is a nucleotide excision repair sub-pathway that preferentially removes lesions from the DNA template-strand stalling RNA polymerase (RNAP) elongation complexes (ECs). In bacteria, the superfamily 2 Mfd translocase mediates TCR by displacing stalled ECs and recruiting Uvr(A)B. Using cryo-electron microscopy, we previously visualized seven Mfd-EC complexes spanning the

Identifiers

PMID40949946
PMCPMC12424862

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.