Evidence map›Paper›PMID 40949909›Full record

ArticleTranslational pediatrics2025

Combined prediction of fractional exhaled nitric oxide and pulmonary function tests for airway hyperresponsiveness in children with chronic cough.

Li Wang, Yinghong Fan, Jie Hu, Qianqian Li, Ronghua Luo, Yaping Duan, Jiayi Xue, Tao Ai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Li Wang *Department of Pediatric Respiratory Medicine, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Yinghong Fan *Department of Pediatric Respiratory Medicine, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Jie HuDepartment of Pediatric Respiratory Medicine, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Qianqian LiDepartment of Pediatric Respiratory Medicine, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Ronghua LuoDepartment of Pediatric Respiratory Medicine, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Yaping DuanDepartment of Pediatric Respiratory Medicine, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Jiayi XueDepartment of Pediatric Respiratory Medicine, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Tao AiDepartment of Pediatric Respiratory Medicine, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Coughing, as one of the most common symptoms of the respiratory system in children, has a variety of etiologies. This study aimed to explore the predictive value of fractional exhaled nitric oxide (FeNO) combined with pulmonary ventilation function tests for airway hyperresponsiveness (AHR) in children with chronic cough. Methods: A total of 157 children with chronic cough who visited Chengdu Women and Children's Central Hospital from January 2020 to January 2024 were included. They were divided into a positive bronchial provocation test group (n=69) and a negative bronchial provocation test group (n=88) based on the results of the bronchial provocation test. The pulmonary ventilation function parameters and FeNO levels of the two groups were compared, and the predictive value of each index for AHR was evaluated through the receiver operating characteristic (ROC) curve. Results: The forced expiratory volume in the first second (FEV1), FEV1/forced vital capacity (FVC), forced expiratory flow at 25% of FVC exhaled (FEF25), forced expiratory flow at 50% of FVC exhaled (FEF50), forced expiratory flow at 75% of FVC exhaled (FEF75), and maximum mid-expiratory flow (MMEF) of the positive provocation group were significantly lower than those of the negative provocation group, and the FeNO level was significantly higher, with statistically significant differences (P<0.05). Further analysis through the ROC curve revealed that MMEF had the highest predictive efficacy for AHR [area under the curve (AUC) =0.88, 95% confidence interval (CI): 0.82-0.94]; when FeNO was combined with pulmonary ventilation function parameters, the combination of MMEF and FeNO had the best predictive efficacy (AUC =0.91, 95% CI: 0.86-0.96), with optimal cut-off values of 67.05% and 20.50 ppb. Conclusions: The combination of FeNO and MMEF can effectively predict AHR in children with chronic cough and has significant clinical value for the differential diagnosis of chronic cough etiology.

Indexed as

airway hyperresponsiveness (AHR)chronic coughFractional exhaled breath nitric oxidepulmonary function test

Identifiers

PMID40949909
PMCPMC12433067

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.