ArticleFrontiers in genetics2025
Comparative analysis of blood whole transcriptome profiles in Yili horses pre- and post-5000-meter racing.
Article in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses.Equine veterinary journal · 2026Article
- Long non-coding RNAs in exercise: the hidden regulators of adaptation.Pflugers Archiv : European journal of physiology · 2026Review
- Effects ofBiology · 2026Article
- Molecular Mechanisms Underlying Differences in Athletic Ability in Racehorses Based on Whole Transcriptome Sequencing.Biology · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study employed Yili horses participating in a 5000-meter race as a model to investigate exercise-induced gene expression alterations in peripheral blood using whole transcriptome sequencing. Jugular vein blood samples from the three leading horses were collected pre- and immediately post-race, yielding 2,171 differentially expressed mRNAs (2,080 upregulated, 91 downregulated), 4,375 differentially expressed LncRNAs (4,354 upregulated), and 68 differentially expressed circRNAs (64 upregulated). GO/KEGG analyses demonstrated significant enrichment of differential mRNAs in transmembrane transport function and pivotal signaling pathways (cAMP, MAPK, PI3K-Akt). Differential lncRNAs targeted neuro-signaling pathways (e.g., Neuroactive ligand-receptor interaction, Calcium signaling) and developmental regulators (stem cell pluripotency). Source genes of circRNAs were enriched in axon guidance and immune-related T cell receptor signaling. Molecular functions converged on transporter/receptor activity (mRNA/lncRNA) and nucleic acid/GTP binding (circRNA source genes). The protein-protein interaction analysis identified ten central genes within the heat shock protein family, such as
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