Evidence map›Paper›PMID 40949823›Full record

ArticleClinical ophthalmology (Auckland, N.Z.)2025

Demographic Characteristics, Contributing Risk Factors, and Prognosis of

Chuwei Lu, Jiajia Wang, Jiaxu Hong, Jianjiang Xu, Xujiao Zhou, Lijia Tian, Qihua Le

Abstract read
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In one paragraph

Article in Clinical ophthalmology (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chuwei Lu *Department of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, People's Republic of China.
Jiajia Wang *Department of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, People's Republic of China.
Jiaxu HongDepartment of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, People's Republic of China.
Jianjiang XuDepartment of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, People's Republic of China.
Xujiao ZhouDepartment of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, People's Republic of China.
Lijia TianDepartment of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, People's Republic of China.
Qihua LeDepartment of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To investigate the demographic characteristics, contributing risk factors, and prognostic outcomes of Patients and Methods: This single-center, retrospective study included 145 patients (147 eyes) diagnosed with AK based on IVCM findings at the Eye & ENT Hospital of Fudan University from April 2009 to September 2024. Demographic information, clinical features at presentation, contributing risk factors (if identified), treatment strategies, and final visual outcomes were retrieved in the medical records and analyzed using descriptive statistics. Results: The median age of patients was 51 years old, with 98.6% of infections being unilateral. Corneal trauma (62.1%) was the leading risk factor overall, whereas contact lens wear was the independent risk factor among children and adolescents. The most common clinical features at presentation were stromal infiltrate (60.6%) and deep stromal ulcers (36.5%). Anti-AK therapy was mainly composed of polyhexamethylene biguanide (PHMB), chlorhexidine, propamidine isethionate (Brolene) and metronidazole. Surgical interventions were required in 24 eyes, with evisceration/enucleation identified as an independent predictor of poor visual prognosis. Conclusion: This study provides valuable epidemiological insights into AK in Eastern China, underscoring the need for improved prevention, early diagnosis, and evidence-based treatment protocols to guide clinical management.

Indexed as

Acanthamoeba keratitiscontributing risk factorsdemographic characteristicsin vivo confocal microscopyprognosis

Identifiers

PMID40949823
PMCPMC12433226

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.