ArticleFrontiers in surgery2025
Oral
Article in Frontiers in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aims to investigate the effect of oral Methods: A rabbit lumbar lateral interbody fusion model was established. Different treatments were administered to each group, including the control group (CON), oral ES extract group (ES), interbody fusion group (IBF) and interbody fusion combined with oral ES group (IBF/ES). Ten weeks after surgery, micro-CT was used to assess intervertebral bone fusion. Bone trabecula parameters, including bone volume fraction (BV/TV), trabecular number (Tb.N) and trabecular thickness (Tb.Th), were measured. Histological analyses, including Masson and HE staining, were used to evaluate angiogenesis and bone growth in the endplate. Results: The micro-CT at the 10th postoperative week showed significant bone tissue regeneration and stable fusion in the IBF/ES groups. Fusion scores, BV/TV, Tb.N and Tb.Th were significantly higher in the IBF/ES groups compared to the other groups. In addition, Masson and HE staining indicated evident vascular ingrowth and new bone formation after oral ES extract treatment. Among the four groups, the IBF/ES groups showed the most significant bone formation and the best fusion effect. Conclusion: This study suggested that oral ES extract after spine surgery can significantly enhance the effectiveness and success rate of lumbar lateral fusion surgery by promoting endplate vascularization and bone formation.
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