Advancements in Monte Carlo simulations with gMicroMC: reactive species build-up promotes radical-radical reactions at Flash dose rates.

Miguel Molina-Hernández, Patrícia Gonçalves, Yujie Chi, João Seco

Abstract readPreprint

In one paragraph

Article in ArXiv, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Miguel Molina-HernándezGerman Cancer Research Center, Biomedical Physics in Radiation Oncology, Heidelberg, Germany.

Patrícia GonçalvesLaboratory of Instrumentation and Experimental Particles Physics, Lisbon, Portugal.

Yujie ChiPhysics Department, The University of Texas at Arlington, Arlington, Texas, United States of America.

João SecoGerman Cancer Research Center, Biomedical Physics in Radiation Oncology, Heidelberg, Germany.

Funding

Development of the next-generation GPU-based Monte Carlo simulation platform for radiation-induced DNA damage calculationsR15CA256668 · NCI · UNIVERSITY OF TEXAS ARLINGTON · PI CHI, YUJIE · 2021 to 2021

$447k

NCI NIH HHS R15 CA256668

6 · The paper itself

Abstract

Ultra-high dose rate irradiations to water indicate an enhancement of radical-radical reactions, which could potentially correlate with the Flash effect. The purpose of this work was to extend gMicroMC to support multiple pulse simulations and Flash dose rates, and to investigate, in a pure water model, the mechanisms underlying the enhancement of radical-radical reactions under Flash conditions. gMicroMC, a GPU-based Monte Carlo track-structure algorithm, was extended to simulate multiple pulses. Pure water was exposed to multiple 70 MeV protons pulses delivering up to 20 Gy. The pulse dose rate was set to 2 · 10

Identifiers

PMID40949757

PMCPMC12425020

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.