SynthesisPeerJ2025
Can the triglyceride-glucose index predict the risk of stroke? A meta-analysis of high-quality studies with 12.8 million participants.
Synthesis in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Triglyceride-glucose index and abnormal blood pressure in adults aged over 70 years: real-world data evidence.BMC cardiovascular disorders · 2026Article
- Joint association of triglyceride-glucose (TyG) and atherogenic index of plasma (AIP) with stroke risk: findings from a nationwide prospective cohort.Cardiovascular diabetology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The triglyceride-glucose index (TyG) has been actively researched for predicting several diseases. However, high-quality evidence assessing its ability to predict stroke is lacking. We conducted a meta-analysis of high-quality studies examining if TyG can predict stroke in the general population. Methods: Embase, PubMed, CENTRAL, Web of Science, and Scopus databases were searched until 13th January 2025. Cohort studies on the general population, excluding those with baseline stroke or cardiovascular disease, with a minimum follow-up of four years and reporting an adjusted association between TyG and stroke were included. TyG was assessed as both a categorical and continuous variable. Results: A total of 13 studies with 12,898,434 individuals were eligible. The overall incidence of stroke was 0.89%. Meta-analysis indicated a statistically significant increased risk of stroke between higher vs lower values of TyG (risk ratio (RR): 1.27 95% confidence interval (CI) [1.19-1.35] Conclusion: High TyG is associated with increased risk of stroke in the general population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.